Pharmacology Research

KEY FINDING: Treatment with rhEPO and cEPO-Fc significantly improves the neurological outcome of mice after spinal cord ischemia.

KEY FINDING: The pooled effect size of the 28 studies was 0.54, 95% CI: 0.47–0.61, p < 0.01, indicating that measures to mitigate BSCB damage significantly improved in reducing overall EB leakage.

KEY FINDING: Orientin effectively mitigated cell apoptosis, neuroinflammation, and oxidative stress in impaired tissues after spinal cord injury in rats.

KEY FINDING: Puerarin reduces myocardial apoptosis by reducing lactic acid production, inhibiting inflammatory response, inhibiting oxidative stress, opening the potassium channel and activating protein kinase C (PKC), promoting myocardial angiogenesis and inhibiting autophagy.

KEY FINDING: TMP exhibits neuroprotective effects against ischemic cerebrovascular diseases by inhibiting calcium overload, glutamate excitotoxicity, oxidative stress, inflammation, and apoptosis, while also protecting the blood-brain barrier and enhancing synaptic plasticity.

KEY FINDING: Muscone reduced the levels of LDH, TNF-α, and MDA after injury, and upregulated the level of SOD.

KEY FINDING: Berberine and mubritinib protected BBSCB from oxygen–glucose deprivation and reoxygenation stress in vitro.

KEY FINDING: SAFit2 ameliorates nerve injury-induced neuropathic pain by reducing neuroinflammation.

KEY FINDING: Oxidative stress plays a vital role in secondary injury after SCI, leading to damage of biological macromolecules, ion imbalances, and mitochondrial dysfunctions.

KEY FINDING: sCLU is associated with inflammatory responses, tissue degeneration, and cellular apoptosis during acute and subacute traumatic SCI.