NeuroReport, 2024 · DOI: 10.1097/WNR.0000000000002054 · Published: May 10, 2024
Spinal cord injury (SCI) involves a primary mechanical injury followed by a secondary injury. The secondary injury, often more severe, involves biochemical changes like ischemia and lack of neurotrophic factors. These changes lead to inflammation and oxidative stress, damaging the spinal cord further. Orientin, a compound from medicinal plants, has anti-inflammatory, antioxidant, and neuroprotective properties. This study explores whether orientin can aid SCI repair by reducing inflammation and oxidative stress, and by inhibiting the p38MAPK/iNOS signaling pathway. Rats with SCI were treated with orientin, and the study assessed their functional recovery, tissue damage, cell apoptosis, and relevant protein expression. The results suggest that orientin can promote SCI repair by reducing oxidative stress and inflammatory response, reducing cell apoptosis and suppressing p38MAPK/iNOS signaling.
Orientin shows promise as a therapeutic candidate for spinal cord injury due to its anti-inflammatory, antioxidant, and anti-apoptotic effects.
The study suggests that inhibiting the p38MAPK/iNOS signaling pathway is a potential avenue for SCI therapy, and orientin can effectively suppress this pathway.
Orientin can protect neurons and promote nerve regeneration, which are crucial for the recovery of motor function after SCI.