Pharmacology Research

KEY FINDING: GA-DM induces apoptosis in human B-cell lymphoma cell lines DB and Toledo, and orchestrates autophagy and apoptosis in the murine B-cell lymphoma cell line A20.

KEY FINDING: Oligo-L treatment significantly improved neuropathic pain and motor function performance in rats with SCI from the first week post-injury.

KEY FINDING: Daytime and nighttime pain levels (Visual Analog Scale) improved after botulinum toxin type A injection.

KEY FINDING: qMT PSR measurements reflect the myelination status of the white matter tissue. The riluzole treatment group indicated significantly higher PSR values in white matter voxels at the epicenter of injury compared to the HBC vehicle treatment group.

KEY FINDING: ACY-1215 ameliorated SNI-induced pain starting from Day 7 post-SNI operation, achieving relatively stable efficacy by Day 13 in both male and female mice.

KEY FINDING: The desflurane group had greater median motor strength than the sevoflurane group towards the final follow-up when the desflurane group had median motor strength of 3 [interquartile range (IQR): 1-4] and sevoflurane group had a median motor strength of 1 (IQR: 0-2.25); p=0.014.

KEY FINDING: The combination of LGZ and SIN significantly alleviated pain-like behaviors in CCI rats in a time- and dose-dependent manner, demonstrating superior therapeutic effects compared to LGZ or SIN alone.

KEY FINDING: Teriparatide treatment significantly enhanced motor function recovery post-SCI in rats, as assessed by open field tests and BBB scoring.

KEY FINDING: Ginsenoside Rd (GSRd) has shown protective effects in neurological diseases such as ischemic stroke, spinal cord injury, Alzheimer's disease and Parkinson's disease.

KEY FINDING: Pelargonidin significantly attenuated neuropathic pain, improved motor performance, and reduced weight loss in rats with SCI.