Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 601-610 of 639 results
Neural Regeneration Research, 2020 • January 9, 2020
N-formyl peptide receptors (FPRs) were first identified upon phagocytic leukocytes, but more than four decades of research has unearthed a plethora of non-myeloid roles for this receptor family. Rapid...
KEY FINDING: FPRs are implicated in neurogenesis and neuronal differentiation, suggesting they could be a target for neuronal regeneration therapies.
Scientific Reports, 2020 • January 21, 2020
This study identifies 2-methoxy-1,4-naphthoquinone (RAD618) as a natural compound that enhances the viability of olfactory ensheathing cells (OECs), which are crucial for neural repair. RAD618 stimula...
KEY FINDING: 2-methoxy-1,4-naphthoquinone (RAD618) strongly stimulates OEC proliferation over several weeks in culture while maintaining the OEC phenotype.
Neurotherapeutics, 2020 • February 18, 2020
The study demonstrates that the leukotriene receptor antagonist Montelukast improves memory in a synucleopathy animal model of dementia. The underlying scientific rational is based on the finding that...
KEY FINDING: Expression of 5-lipoxygenase, the rate-limiting enzyme for leukotriene production, was found to be elevated in brains with DLB.
Frontiers in Pharmacology, 2020 • February 11, 2020
This study investigated the mechanism of ER stress-induced apoptosis and the protective action of fibroblast growth factor 22 (FGF22) in vivo in a rat model of spinal cord injury (SCI). The results de...
KEY FINDING: FGF22 administration promoted recovery and increased neuron survival in the spinal cord lesions of model mice. The protective effect of FGF22 is related to decreased expression of CHOP, GRP78, caspase-12, XBP1, Eif-2a and Bad which are ER stress-induced apoptosis response proteins.
International Journal of Molecular Sciences, 2020 • March 12, 2020
This study describes the development of NVP-13, a human-specific antisense oligonucleotide (ASO) drug candidate designed to inhibit TGFβ signaling by targeting TGFBR2 mRNA. Through a rigorous screenin...
KEY FINDING: The study identified NVP-13 as a highly specific and stable ASO drug candidate targeting TGFBR2 mRNA.
Cells, 2020 • March 27, 2020
The study investigates the effect of NeuroHeal, a combination of Acamprosate and Ribavirin, on sensory fiber regeneration and neuropathic pain in rat models of peripheral nerve injury. The treatment a...
KEY FINDING: NeuroHeal treatment reduced signs of neuropathic pain in rat models of spare nerve injury and nerve crush.
Saudi Med J, 2020 • April 1, 2020
This study investigated the effects of syringaldehyde (SA) on spinal cord ischemia (SCI) in rabbits, focusing on its impact on oxidative stress and inflammation. The researchers induced SCI in rabbits...
KEY FINDING: Syringaldehyde treatment significantly increased Glutathione peroxidase enzyme activity levels compared to the ischemia group.
Brazilian Journal of Medical and Biological Research, 2020 • April 1, 2020
This study investigates the potential of VPA encapsulated in PLGA microfibers, produced via coaxial electrospinning, for the treatment of spinal cord injury (SCI). The microfibers exhibited suitable m...
KEY FINDING: VPA was successfully encapsulated in PLGA microfibers using coaxial electrospinning, creating fibers with suitable morphology and mechanical characteristics for SCI applications.
International Journal of Molecular Sciences, 2020 • May 15, 2020
The study demonstrated that the association of PEAum and Paracetamol, in a low dose (5 mg/kg + 30 mg/kg), reduced hyperalgesia, mast cell activation, c-Fos and nerve growth factor (NGF) expression, ne...
KEY FINDING: PEAum–Paracetamol association reduced hyperalgesia, mast cell activation, c-Fos and nerve growth factor (NGF) expression, neural histological damage, cytokine release, and apoptosis in a rat model of sciatic nerve injury (SNI).
J Cell Mol Med, 2020 • July 1, 2020
This study developed a GFs-based delivery system (called GFs-HP) that consisted of basic fibroblast growth factor (bFGF), nerve growth factor (NGF) and heparin-poloxamer (HP) hydrogel through self-ass...
KEY FINDING: GFs-HP hydrogel promotes motor functional recovery after SCI, as shown by footprint analysis and BBB locomotion scores.