Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the Rat

Molecules, 2025 · DOI: 10.3390/molecules30010086 · Published: December 29, 2024

Simple Explanation

Traumatic spinal cord injury (SCI) can lead to gastric ulcers and bleeding. Current treatments like omeprazole have side effects, prompting the search for safer alternatives. This study investigates methyl eugenol (ME), a natural compound, for its potential to protect the stomach lining in rats with SCI. ME's protective effects were examined against gastric mucosal damage in a rat model of SCI. The results suggest that methyl eugenol can protect the gastric mucosa from damage caused by SCI, potentially through its antioxidant properties.

Study Duration

Not specified

Participants

Wistar rats (200–250 g)

Evidence Level

Not specified

Key Findings

1
Methyl eugenol exhibits a dose-dependent gastroprotective effect against gastric damage induced by spinal cord injury in rats.
2
The gastroprotective effect of methyl eugenol is comparable to that of omeprazole, a commonly used medication for gastric ulcers.
3
The protective effects of methyl eugenol are partly mediated by the enzymatic activities of glutathione peroxidase and catalase, suggesting an antioxidant mechanism.

Research Summary

This study explores the gastroprotective effects of methyl eugenol (ME) in a rat model of spinal cord injury (SCI). SCI often leads to gastric ulceration, and current treatments have adverse effects. The findings indicate that ME provides significant gastroprotection against SCI-induced gastric damage, even in the presence of diclofenac or ketorolac. This protection is linked to the enzymatic activities of glutathione peroxidase and catalase. The study concludes that methyl eugenol may be a promising alternative for managing gastric ulcers in patients with traumatic spinal cord injuries due to its significant gastroprotective effects.

Practical Implications

Alternative Therapy

Methyl eugenol could serve as an alternative therapeutic agent for managing gastric damage associated with spinal cord injury, potentially reducing the reliance on drugs with significant side effects.

Antioxidant Mechanism

The study highlights the importance of antioxidant mechanisms, specifically glutathione peroxidase and catalase, in protecting against SCI-induced gastric damage.

Further Research

Additional research is needed to fully elucidate the mechanisms of action of methyl eugenol and to evaluate its efficacy and safety in human clinical trials.

Study Limitations

1
The study was conducted on rats, and the results may not be directly applicable to humans.
2
The specific mechanisms of action of methyl eugenol were not fully elucidated.
3
The long-term effects and potential toxicity of methyl eugenol were not assessed.

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