Pharmacology Research

KEY FINDING: Spinal cord injury accelerates aortic atherosclerotic disease and associated risk factors in ApoE-/- mice.

KEY FINDING: EA treatment increased pain threshold in SNL rats, indicating pain relief, while the P2X7R agonist BzATP suppressed this EA-induced increase.

KEY FINDING: CTP treatment could improve the functional recovery, as well as suppress the apoptosis, alleviate inflammatory and oxidative response in SCI mice.

KEY FINDING: Early escitalopram administration suppressed spastic behaviors during the swimming test in rats with contusive SCI.

KEY FINDING: The addition of transdermal neostigmine and glycopyrrolate significantly reduced the time to bowel evacuation compared to standard of care alone.

KEY FINDING: A 70-year-old man with tetraplegia developed a coma after gabapentin administration, despite normal renal and liver function.

KEY FINDING: A total of 379 LAN publications were identified, with the majority published in Chinese. The review categorizes these publications based on indications, including motor, glandular, pain, and aesthetic uses.

KEY FINDING: High-dose MP administration significantly reduced bone mineral density (BMD) in the distal femur and proximal tibia of SCI rats compared to SCI-vehicle animals.

KEY FINDING: The study identified 109 active compounds and 5440 prediction targets from Buyang Huanwu Decoction, with 98 active components and 49 related prediction targets being strongly linked to Spinal Cord Injury.

KEY FINDING: EA treatment relieves mechanical allodynia and thermal hyperalgesia in CCI rats, as demonstrated by increased MWT and TWL values compared to the CCI group.