Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 321-330 of 639 results
Frontiers in Neurology, 2022 • November 7, 2022
This protocol describes a prospective, mock-efficacy, dose exploration trial to test the feasibility of administering gabapentin in the acute setting as an intervention for neurorecovery after spinal ...
KEY FINDING: The study aims to assess the feasibility of recruiting the target population, delivering the drug treatment protocol, maintaining blinding, and retaining participants.
Dose-Response: An International Journal, 2022 • October 1, 2022
This study used iTRAQ proteomics to investigate the molecular mechanisms of hyperbaric oxygen therapy (HBOT) in a rat model of spinal cord injury (SCI). The study identified differentially expressed p...
KEY FINDING: HBOT influences biological processes such as oxygen transport, gas transport and regulation of T cell proliferation.
Canadian Family Physician, 2022 • December 1, 2022
This clinical review focuses on prescribing patterns for three common complications of spinal cord injury (SCI): pain, muscle spasms, and recurrent urinary tract infections (UTIs). The review highligh...
KEY FINDING: Neuropathic pain is highly prevalent in SCI patients, affecting approximately 75% of patients.
PLoS ONE, 2023 • January 20, 2023
The RILUSCI trial is designed to assess the safety and efficacy of riluzole in treating spasticity in patients with chronic spinal cord injury (SCI). The study employs a phase 1b/2b adaptive, multicen...
KEY FINDING: This clinical trial will be the first to document the safety and efficacy of riluzole as a means of reducing spasticity in patients with chronic SCI.
Journal of NeuroEngineering and Rehabilitation, 2023 • January 18, 2023
This paper studied the intrinsic and reflexive ankle joint resistance within participants treated with BoNT-A injections to reduce spasticity. On group-level, our hypothesis was only confirmed for the...
KEY FINDING: At group-level, the expected joint resistance reduction due to BoNT-A injections was only observed in the MAS (overall resistance).
Frontiers in Pharmacology, 2024 • June 27, 2024
This review discusses the use of hydrogels combined with neural stem cells (NSCs) for spinal cord injury (SCI) regeneration. It highlights the limitations of endogenous regeneration and the potential ...
KEY FINDING: NSCs secrete active compounds that promote nerve tissue regeneration, improve nerve cell survival, neuroplasticity, and neuroimmune modulation.
ASSAY and Drug Development Technologies, 2015 • September 1, 2015
The study developed two HCA assays to investigate reactive-like changes in astrocytes: one measuring the stellation index (GFAP+ process area/cell body area) and another monitoring the expression of g...
KEY FINDING: The GFAP morphology assay is suitable for counter-screening with a Z-factor of 0.44 – 0.03.
Int. J. Mol. Sci., 2024 • December 11, 2024
Nanotechnology has emerged as a transformative force in neuroscience, addressing challenges that have long impeded progress in the diagnosis and treatment of CNS disorders. Theranostic NPs stand out a...
KEY FINDING: Nanoparticles can be engineered to cross the blood-brain barrier (BBB) using passive targeting, active targeting, and stimuli-responsive systems, enhancing drug delivery to the CNS.
Molecular Therapy: Methods & Clinical Development, 2021 • December 1, 2021
This study reports the unexpected finding that AAV vectors accumulate in the pineal gland following injections into the brain, spinal cord, or cerebrospinal fluid (CSF). Different AAV serotypes, inclu...
KEY FINDING: AAV vectors accumulate in the pineal gland following injections into the brain, spinal cord, or cerebrospinal fluid.
Frontiers in Neuroscience, 2015 • September 2, 2015
This study investigates the functionalization of nanoparticles (NPs) with nerve growth factor (NGF) and glial cell-line derived neurotrophic factor (GDNF) to support regeneration in the nervous system...
KEY FINDING: Covalent binding of NGF to PEI-NPs impaired its bio-functionality, while non-covalent binding successfully differentiated PC12 cells.