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  4. Emergence of taurine as a therapeutic agent for neurological disorders

Emergence of taurine as a therapeutic agent for neurological disorders

Neural Regeneration Research, 2024 · DOI: https://doi.org/10.4103/1673-5374.374139 · Published: January 1, 2024

PharmacologyNeurology

Simple Explanation

Taurine, a naturally occurring amino acid, has shown potential in protecting against various neurological disorders like stroke, epilepsy, and spinal cord injury. It works by reducing inflammation, oxidative stress, and regulating calcium levels in cells. This review discusses how taurine affects different neurological diseases, highlighting its potential to protect nerve cells and improve brain function. It also explores how taurine interacts with brain chemicals and cell processes at a molecular level. Given its effectiveness in experimental studies, taurine should be further explored as a possible treatment for neurological conditions. More research, including clinical trials, is needed to confirm its benefits and understand exactly how it works.

Study Duration
Not specified
Participants
Not specified
Evidence Level
Review

Key Findings

  • 1
    Taurine can modulate endoplasmic reticulum stress, Ca2+ homeostasis, and neuronal activity at the molecular level, effectively protecting against neurological disorders.
  • 2
    Taurine exhibits neuroprotective effects by acting as an agonist at γ-amino butyric acid (GABA) and glycine receptors, modulating Ca2+ influx, and preventing excitotoxicity and oxidative stress.
  • 3
    Studies suggest taurine can improve cognitive function in Alzheimer's disease, reduce dopaminergic neurodegeneration in Parkinson's disease, and decrease the severity of cerebral ischemia.

Research Summary

Taurine, a sulfur-containing amino acid, plays a crucial role in maintaining cellular homeostasis and exhibits neuroprotective effects against various neurological disorders. Taurine modulates various cellular processes such as ER stress, Ca2+ homeostasis, and oxidative stress, and has shown promise in treating Alzheimer's disease, Parkinson's disease, epilepsy, and cerebral ischemia. While taurine shows potential as a therapeutic agent, further studies are necessary to assess its toxicity, identify its signaling targets, and fully understand its pharmacological effects on different organs.

Practical Implications

Drug Development

Taurine could be a basis for new drugs or supplements aimed at treating central nervous system disorders.

Alternative Medicine

Taurine may offer a safer alternative or complementary treatment option for those seeking neuroprotection.

Clinical Research

Further clinical studies are warranted to determine the efficacy of taurine in treating neurological diseases in humans.

Study Limitations

  • 1
    Further toxicity studies are required before taurine can be developed into a drug.
  • 2
    More research is needed to determine the potential signaling targets of taurine in various neurological diseases.
  • 3
    The precise pharmacological effects that taurine exerts on the various organs of the body need better understanding.

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