Pain Management Research

KEY FINDING: Tensile loading can promote neuronal cell differentiation, neurite outgrowth and orientation, increased endogenous opioid receptors, reduced fibrosis and intraneural scar formation, improved nerve regeneration and remyelination.

KEY FINDING: TNF-α, CCL2, and CXCL1 are significantly increased in the TNC region of ION-CCI rats, suggesting their involvement in trigeminal neuralgia.

KEY FINDING: Human and rodent DRG neurons exhibit significant functional and physiological differences, particularly in sodium channel composition and action potential properties, suggesting human DRG neurons may be a more clinically relevant model for pain studies.

KEY FINDING: MaR1 demonstrated a more robust ability to promote sensory and motor function recovery in mice after sciatic nerve crush injury than NGF.

KEY FINDING: Upregulated autophagic activities may help myelin clearance, promote nerve regeneration, and attenuate pain behavior after nerve damage.

KEY FINDING: Intradiscal injection is a minimally invasive outpatient procedure that can improve pain quality for patients with LBP or lumbar disc herniation (LDH).

KEY FINDING: Huc-MSCs-derived exosomes alleviated mechanical allodynia and thermal hyperalgesia in CFA-induced inflammatory pain model.

KEY FINDING: Significant differences exist in transcriptional responses to PNI and SCI, particularly in regeneration-associated genes (RAGs) and long non-coding RNAs (lncRNAs).

KEY FINDING: MiRNAs regulate gene expression by binding to mRNAs, affecting their stability and translation, and are implicated in neuropathic pain through dysregulation in the DRG and spinal cord.

KEY FINDING: Andro injections significantly reduced mechanical allodynia (pain from a stimulus that doesn't normally cause pain) compared to saline treatment.