Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 291-300 of 682 results
HRB Open Research, 2024 • September 2, 2024
This study protocol outlines a phase 2 randomized trial to assess exoskeleton walking for neuropathic pain after spinal cord injury. The trial aims to address the need for non-pharmacological treatmen...
KEY FINDING: The study will assess recruitment and retention rates for an exoskeleton-based walking intervention.
Cellular and Molecular Neurobiology, 2025 • January 12, 2025
This study investigates changes in neuronal activation along the sensory neuroaxis in a rat model of spinal cord injury (SCI) exhibiting below-level pain. The findings reveal that SCI amplifies the en...
KEY FINDING: Spinal cord injury (SCI) amplifies the activation of dorsal horn (DH) neurons in a stimulus-dependent manner, primarily after noxious stimulation.
Neurochemical Research, 2025 • January 16, 2025
This study investigates the mechanisms underlying neuropathic pain (NP), focusing on the role of mTOR in astrocytes. It finds that mTOR is activated in astrocytes following chronic constriction injury...
KEY FINDING: mTOR is activated in astrocytes within the spinal cord following chronic constriction injury (CCI), contributing to neuropathic pain.
Clinical Case Reports, 2025 • January 1, 2025
This case report presents a 60-year-old male with a cervical spinal cord injury (SCI) who experienced significant improvements in motor function, spasticity, and pain after receiving spinal cord stimu...
KEY FINDING: The patient experienced a 60% improvement in spasticity and a 50% improvement in mobility of his right upper extremity following SCS.
Healthcare, 2025 • January 26, 2025
This study investigates the relationship between Pressure Pain Threshold (PPT) and various clinical, cognitive, and motor factors in Spinal Cord Injury (SCI) patients. It uses a cross-sectional analys...
KEY FINDING: Incomplete SCI lesions are linked to increased pain sensitivity (lower PPT), suggesting altered neural processing exacerbates pain responses.
PLOS ONE, 2025 • February 27, 2025
This study investigated the role of anoikis-related genes in neuropathic pain (NP), particularly in lumbar disc herniation (LDH). Machine learning algorithms identified six key genes (HGF, MMP13, ABL1...
KEY FINDING: Six key anoikis-related genes (HGF, MMP13, ABL1, ELANE, FASN, and LINC00324) were identified as having diagnostic value for NP.
Cureus, 2025 • February 22, 2025
This case report discusses the effective use of spinal cord stimulation (SCS) to treat lower limb pain caused by conus medullaris syndrome. This case highlights the diagnostic difficulties associated ...
KEY FINDING: The patient experienced electric shock-like pain during epidural anesthesia for laparoscopic colon resection, which persisted postoperatively, leading to the diagnosis of conus medullaris syndrome.
The Journal of Spinal Cord Medicine, 2022 • April 1, 2022
Chronic pain after spinal cord injury significantly affects quality of life, necessitating a shift towards non-opioid treatments due to the opioid crisis. The review highlights antiepileptic and antid...
KEY FINDING: Antiepileptic drugs like pregabalin and gabapentin have demonstrated efficacy in managing chronic SCI-related neuropathic pain.
The Journal of Spinal Cord Medicine, 2021 • July 1, 2021
This study examined the relationships between physical activity (PA) levels and the secondary conditions of chronic pain and fatigue in individuals with spinal cord injury (SCI) using a mobile health ...
KEY FINDING: Light-intensity PA showed a positive linear relationship with task-specific pain, indicating that as light activity increases, task-specific pain may also increase.
The Journal of Spinal Cord Medicine, 2021 • July 1, 2020
This pilot study aimed to identify differences in resting cerebral blood flow between individuals with spinal cord injury (SCI)-related neuropathic pain (NP) and healthy controls using arterial spin l...
KEY FINDING: Individuals with SCI-related neuropathic pain exhibited significantly reduced resting blood flow in the cerebellum (specifically Crus I/II), the rostral ventromedial medulla, and the left insular cortex compared to healthy controls.