Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 151-160 of 682 results
JCI Insight, 2023 • October 12, 2023
This study demonstrates that spinal Npy1r-expressing DH interneurons that coexpress Grp are evolutionarily conserved across rodent, nonhuman primate, and human and are necessary for the efficacy of sp...
KEY FINDING: Y1-INs in the spinal dorsal horn are excitatory neurons that segregate into three distinct subpopulations based on coexpression of Npy1r with Grp, Npff, or Cck.
iScience, 2023 • November 17, 2023
The study demonstrates that increased cell surface expression of the P2X4 receptor induces hypersensitivity to mechanical stimulation and hyperexcitability in spinal cord neurons in both male and fema...
KEY FINDING: Increased cell surface expression of P2X4 induces hypersensitivity to mechanical stimulations and hyperexcitability in spinal cord neurons of both male and female naive mice.
J South Med Univ, 2023 • October 1, 2023
This study investigated the therapeutic effect of metformin on pathological pain in mice with radiation dermatitis and explored the underlying mechanism. The results showed that metformin can signific...
KEY FINDING: Metformin alleviated radiation dermatitis symptoms in mice compared to the model group and a positive control group (Gabapentin).
Journal of Orthopaedic Surgery and Research, 2023 • November 7, 2023
This retrospective study investigated the impact of time from injury to surgery on neuropathic pain (NeP) development after traumatic spinal cord injury (SCI). The study found that delayed surgical in...
KEY FINDING: Age at injury, Injury Severity Score, and neurological level of injury are independent risk factors for the development of NeP in both AIS A and AIS B, C, and D subgroups.
Cureus, 2023 • October 11, 2023
The utilization of BTX-A in the treatment of various forms of neuralgia and neuropathic pain shows promising outcomes in terms of reducing pain and improving overall patient outcomes. BTX-A's mechanis...
KEY FINDING: BTX-A has demonstrated effectiveness in treating various conditions, including postherpetic neuralgia (PHN), auriculotemporal neuralgia (ATN), occipital neuralgia (ON), leprosy-induced neuropathic pain (LIN).
Molecular Pain, 2023 • November 10, 2023
The study investigates the role of HDAC6 in neuropathic pain (NP) induced by chronic constriction injury (CCI) in mice, finding that HDAC6 expression is upregulated in the spinal cord following CCI. T...
KEY FINDING: HDAC6 expression is upregulated in the spinal cord following chronic constriction injury (CCI).
Pharmaceuticals, 2023 • November 18, 2023
This study investigated the effect of URB937, a blood–brain barrier impermeant FAAH inhibitor, on experimentally induced mechanical allodynia in an animal model of trigeminal neuralgia. URB937 treatme...
KEY FINDING: URB937 treatment prevented the development of mechanical allodynia in rats subjected to chronic constriction injury of the infraorbital nerve (IoN-CCI).
PAIN Reports, 2023 • January 1, 2023
The study aimed to identify common sensory phenotypes across different chronic pain cohorts (CRPS and LBP) to understand potential underlying mechanisms. Cluster analysis of quantitative sensory testi...
KEY FINDING: Two clusters were identified based on QST measures in the painful area, with patients from both CRPS and LBP cohorts present in each cluster.
Biology Direct, 2023 • December 6, 2023
This study demonstrated the critical role of spinal Apoe in the maintenance of inflammatory pain. Apoe knockout exerts regulatory effects on the function of astrocytes, microglial cells, and neurons, ...
KEY FINDING: Apoe levels were markedly upregulated at 2 h and on days 1 and 3 post-CFA treatment, and Apoe was exclusively expressed in the astrocytes.
J BONE ONCOL, 2023 • October 30, 2023
This study establishes and characterizes an immunocompetent mouse model of prostate cancer-induced bone pain (PCa-CIBP) by injecting RM1-GFP cells into the femur of C57BL/6 mice. The model exhibits os...
KEY FINDING: Intra-femoral injection of RM1 prostate cancer cells in mice led to a progressive increase in hindlimb guarding, indicating spontaneous pain.