Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,381-5,390 of 5,401 results
Exp Neurol, 2010 • November 1, 2010
This study investigates the effects of cycling exercise on the expression of apoptosis-associated microRNAs (miRs) after spinal cord injury (SCI) in rats. SCI leads to increased expression of pro-apop...
KEY FINDING: SCI results in increased expression of miR Let-7a and miR16.
Nat Neurosci, 2010 • December 1, 2010
The study demonstrates substantial spontaneous plasticity of corticospinal axons in primates after spinal cord injury, restoring axon density to 60% of normal levels. This axonal regeneration correlat...
KEY FINDING: After a C7 spinal cord hemisection in adult rhesus monkeys, corticospinal projections exhibited remarkable spontaneous plasticity, with reconstitution of approximately 60% of pre-lesion axon density.
Exp Neurol, 2011 • October 1, 2011
This study investigates the effects of RhoA-inhibiting NSAIDs on oligodendrocyte survival and axonal myelination after spinal cord injury (SCI). The findings demonstrate that ibuprofen and indomethaci...
KEY FINDING: Ibuprofen and indomethacin reduced oligodendrocyte cell death in cultures exposed to TNF-α.
Ann Neurol, 2010 • November 1, 2010
This study investigates the role of PTEN in oligodendrocytes, focusing on its impact on myelin formation and repair. The findings reveal that PTEN is essential for regulating myelin thickness and pres...
KEY FINDING: During development, loss of PTEN in oligodendrocytes leads to excessive myelin formation (hypermyelination).
J Comp Neurol, 2010 • November 1, 2010
This study identifies aquaporin 1 (AQP1) as a distinguishing characteristic of olfactory ensheathing glia (OEG) in the mouse olfactory system. AQP1 is expressed by OEG in the lamina propria, olfactory...
KEY FINDING: AQP1 is expressed in olfactory ensheathing glia (OEG) in both peripheral and central olfactory structures.
Dev Dyn, 2010 • November 1, 2010
This paper presents a method for visualizing 3D relationships in intact and regenerating adult newt spinal cords using fluorescent probes and confocal microscopy. The method involves fixation, decalci...
KEY FINDING: PLP with 0.5% PFA fixative provided the best streptavidin probe penetration while preserving cellular morphology.
JOURNAL OF NEUROTRAUMA, 2010 • December 1, 2010
This study investigates strategies to rescue injured rat cervical motoneurons following C7 ventral root avulsion. The approaches included reimplantation, nerve grafts, and riluzole treatment, both alo...
KEY FINDING: Avulsion without reimplantation resulted in very low numbers of surviving motoneurons.
Dev Neurobiol, 2011 • July 1, 2011
This study investigates the expression and activation of ephexin after spinal cord injury (SCI) in rats. Ephexin, a guanine nucleotide exchange factor, is involved in Eph signaling pathways that can m...
KEY FINDING: Ephexin protein expression increases after SCI, peaking at 4-7 days post-injury and returning to normal levels by 14 days.
Journal of Biological Chemistry, 2011 • January 21, 2011
This study investigates the role of Paired Immunoglobulin-like Receptor B (PIR-B) in axonal regeneration after spinal cord injury (SCI) using PIR-B-knock-out mice. The researchers found that deleting ...
KEY FINDING: Hindlimb motor function, assessed using various tests, did not significantly differ between PIR-B-knock-out and wild-type mice after dorsal hemisection of the spinal cord.
BMC Neuroscience, 2010 • November 23, 2010
This study examines the intrinsic response of long descending propriospinal tract (LDPT) neurons to axotomy following a low thoracic spinal cord injury (SCI) in rats, comparing their response to short...
KEY FINDING: LDPT neurons exhibit a broad down-regulation of genes related to growth factors and axonal regeneration early after a low thoracic spinal cord injury.