Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,371-5,380 of 5,401 results
J Pain, 2010 • November 1, 2010
This study demonstrates that skin incision, even without direct nerve injury, induces the expression of axonal regeneration-related genes in adult rat spinal sensory neurons. The researchers observed ...
KEY FINDING: Skin incision led to a significant increase in ATF3 expression in DRG neurons.
Cell Mol Neurobiol, 2010 • July 14, 2010
This is a retraction note for an article originally published online on July 14, 2010, in Cellular and Molecular Neurobiology. The reason for the retraction is the duplication of a significant amount ...
KEY FINDING: The original article (DOI 10.1007/s10571-009-9449-4) has been retracted.
TISSUE ENGINEERING: Part A, 2010 • October 1, 2010
This study investigates the effect of astrocyte alignment on neuronal growth using a 3D collagen gel culture system, finding that aligned astrocytes enhance neurite outgrowth. The researchers develope...
KEY FINDING: Astrocyte alignment is significantly greater at the edge and middle of tethered rectangular collagen gels compared to unaligned delta zones.
The Journal of Neuroscience, 2010 • July 21, 2010
The study examined the local and remote neuronal responses to neurotrophic factor-secreting cell grafts placed within sites of right C7 hemisection lesions in the rhesus macaque. Six months after gene...
KEY FINDING: Neurotrophic factors (BDNF and NT-3) administered at the site of spinal cord injury in primates promoted regeneration of axons into the local lesion site.
PLoS ONE, 2010 • July 29, 2010
This study investigates the potential of human motor neuron progenitors (hMNPs), derived from human embryonic stem cells (hESCs), to treat spinal cord injury (SCI) in rats. The research demonstrates t...
KEY FINDING: hMNP transplantation suppresses SCI pathogenesis-related signaling pathways, which correlates with enhanced endogenous neuronal survival and neurite branching.
Nat Neurosci, 2010 • September 1, 2010
This study investigates the role of PTEN/mTOR in controlling the regenerative capacity of mouse corticospinal neurons after spinal cord injury. The researchers found that forced up-regulation of mTOR ...
KEY FINDING: Deleting PTEN in adult corticospinal neurons enhances compensatory sprouting of uninjured CST axons.
The Journal of Neuroscience, 2010 • August 11, 2010
This study investigates the potential of genetically attenuating myelin and Semaphorin-mediated inhibition to promote axon regeneration after spinal cord injury. The research focused on serotonergic a...
KEY FINDING: Deleting Nogo, MAG, and NgR1 (three myelin inhibitors) did not enhance serotonergic axon regeneration after complete spinal cord transection.
CELLULAR & MOLECULAR BIOLOGY LETTERS, 2010 • August 14, 2010
The study cloned GFAP cDNA from Gekko japonicus and examined its expression changes after spinal cord transection. GFAP expression increased and then decreased after spinal cord injury (SCI), predomin...
KEY FINDING: GFAP expression in the spinal cord increased after transection, peaking at 3 days, then gradually decreasing.
The Journal of Clinical Investigation, 2010 • September 1, 2010
This commentary discusses a study by Abematsu et al. on neural stem cell transplantation in a mouse model of spinal cord injury (SCI). The study demonstrates that transplanted neural stem cells, when ...
KEY FINDING: Neural stem cell transplantation can reconstruct spinal neuronal circuits in mice with severe spinal cord injury.
The Journal of Neuroscience, 2010 • August 25, 2010
This study challenges the long-standing controversy about whether spinal cord injury (SCI) causes retrograde cell death of corticospinal tract (CST) neurons. By directly assessing CST axons in the med...
KEY FINDING: Only a small fraction of axons in the medullary pyramid showed signs of degeneration after SCI, comparable to uninjured rats.