Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,391-5,400 of 5,401 results
Brain, 2011 • April 1, 2011
This study demonstrates that decorin core protein infusion suppresses Sema3A mRNA and protein levels in CNS injury sites, particularly in leptomeningeal fibroblasts within fibrotic scar tissue. Decori...
KEY FINDING: Decorin infusion reduces Sema3A mRNA and protein levels in cerebral cortex scar tissue.
The Journal of Neuroscience, 2010 • December 1, 2010
The study assessed the impact of soleus (SOL) H-reflex up-conditioning on the recovery of SOL and tibialis anterior (TA) EMG activity and reflexes following sciatic nerve transection and repair in rat...
KEY FINDING: SOL (and probably TA) background EMG activity recovered faster in TU rats than in TC rats.
Surgical Neurology International, 2010 • October 20, 2010
This review summarizes recent advances in translational neuroscience, covering topics from spinal cord regeneration and stroke recovery to brain tumor treatment and epilepsy management. The authors hi...
KEY FINDING: Pten deletion enhances regenerative ability of adult corticospinal neurons following spinal cord injury in animal models.
Molecular Therapy, 2011 • February 1, 2011
This study investigates the efficacy of intraspinal delivery of G-CSF using AAV in an ALS mouse model. The results indicate that intraspinal delivery improves motor functions, delays disease progressi...
KEY FINDING: Intraspinal delivery of AAV-G-CSF improved motor functions, delayed disease progression, and increased survival by 10% in SOD-1 (G93A) mice, longer than after systemic delivery.
Molecular Pain, 2010 • December 17, 2010
The study examined behavioral responses to laser stimulation of Aδ- and C-fibers in rats, both before and after RTX-induced ablation. Recovery of behavioral function progressed from proximal (mid-plan...
KEY FINDING: RTX-induced thermal hypoalgesia is sustained longer than previously thought, particularly for Aδ fibers.
PLoS ONE, 2010 • December 20, 2010
This study aimed to assess the synergistic protective effect of human mesenchymal stem cells (hMSCs) and pituitary adenylate cyclase-activating polypeptide (PACAP) on functional recovery in rats with ...
KEY FINDING: Delayed treatment with PACAP and hMSCs at day 7 post SCI increased the remaining neuronal fibers in the injured spinal cord, leading to better locomotor functional recovery in SCI rats when compared to treatment only with PACAP or hMSCs.
Neural Development, 2011 • January 4, 2011
This study details the cellular and extracellular events during newt spinal cord regeneration after transection injury. It emphasizes the crucial role of meningeal and glial cells in promoting axon re...
KEY FINDING: Axon regeneration following spinal cord transection involves six stages: retraction, growth initiation, wrapping, wisping, spiking, and contact and growth beyond the injury site.
Molecular Pain, 2011 • January 5, 2011
This study investigates whether a preconditioning nerve lesion influences pain sensation and neuroinflammation following a subsequent peripheral nerve injury. The results show that a preconditioning c...
KEY FINDING: A preconditioning crush injury to the tibial nerve significantly attenuated mechanical allodynia and thermal hyperalgesia following partial sciatic nerve ligation (PSNL).
Frontiers in Neurology, 2010 • July 12, 2010
The current surgical technique for longitudinal spinal cord injury has shown success in restoring some motor function and alleviating pain, but there are still many obstacles. Root avulsion injury res...
KEY FINDING: Surgical replantation of avulsed cervical and lumbosacral ventral spinal roots can promote spinal cord regeneration of autonomic and somatic motoneurons.
JOURNAL OF NEUROTRAUMA, 2011 • April 1, 2011
This study investigated the effects of transplanting human glial-restricted progenitors (hGRP) and astrocytes derived from hGRP (hGDA) into a rat model of spinal cord contusion injury. The results sho...
KEY FINDING: Both hGRP and hGDA grafts demonstrated robust survival and extensive migration within the injured spinal cord, with a threefold increase in cell number for hGRP and a twofold increase for hGDA.