Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,361-5,370 of 5,401 results
BMC Neuroscience, 2010 • June 4, 2010
The study examines the intrinsic post-axotomy response of thoracic propriospinal (TPS) neurons following spinal cord injury (SCI), focusing on changes in gene expression at different time points. The ...
KEY FINDING: A strong and early upregulation occurs in the expression of genes involved in the immune/inflammatory response that returned towards normal by 1-week post-injury.
J Comp Neurol, 2010 • August 1, 2010
This study investigated the impact of peripheral nerve injury on the central projections of DRG neurons expressing GFRs, focusing on GFRα1, GFRα2, and GFRα3 after sciatic nerve injury in rats. The key...
KEY FINDING: Sciatic nerve injury caused a widespread increase in nerve fiber labeling for GFRα1 in the lumbar dorsal horn.
PNAS, 2010 • June 22, 2010
The study examines the topographic specificity of sensory axon regeneration in the spinal cord following dorsal root crush, using soluble Nogo receptor peptide (sNgR) and artemin (ART) treatments. sNg...
KEY FINDING: Artemin (ART) treatment promotes topographically specific regeneration of sensory axons after dorsal root crush, while soluble Nogo receptor peptide (sNgR) does not.
Neuron, 2010 • June 10, 2010
The study investigates the role of myelin inhibitors Nogo, MAG, and OMgp in axon regeneration and sprouting after spinal cord injury using genetically modified mice. Results indicate that deleting any...
KEY FINDING: Deleting any one of the inhibitors (Nogo, MAG, or OMgp) enhanced sprouting of corticospinal or raphespinal serotonergic axons.
Nat Rev Neurol, 2010 • July 1, 2010
Stem cell therapy holds promise for treating spinal cord injury (SCI) by potentially replacing damaged cells, providing trophic support, and facilitating axon regeneration. While stem cell transplanta...
KEY FINDING: Stem cell transplantation strategies for SCI include replacing lost or damaged cells (neurons and oligodendrocytes), providing trophic support, and manipulating the environment to facilitate axon regeneration.
Brain Res Bull, 2011 • March 10, 2011
The adult mammalian central nervous system (CNS) faces challenges in recovering from neurotrauma and disease due to axon disruption, neuronal death, target denervation, and functional deficits. Constr...
KEY FINDING: Neurotrophins alone can induce regeneration of sensory axons, but they may not terminate in appropriate target regions without additional guidance signals.
PLoS Biology, 2010 • June 22, 2010
This present study demonstrates that the intracellular levels of NCS1 in adult cortical neurons can be significantly elevated by transduction with a lentiviral vector. Similarly, analogous experiments...
KEY FINDING: NCS1 overexpression in uninjured corticospinal neurons exhibited axonal sprouting across the midline into the CST-denervated side of the spinal cord following unilateral pyramidotomy.
Neurosci Lett, 2010 • September 6, 2010
This study demonstrates that GsMTx4, a mechanosensitive ion channel inhibitor, potentiates neurite outgrowth in PC12 cells when combined with NGF. The peptide's effect is dose-dependent and requires e...
KEY FINDING: GsMTx4, a peptide inhibitor of mechanosensitive ion channels, enhances neurite outgrowth from PC12 cells in the presence of NGF in a dose-dependent manner.
Molecular Therapy, 2010 • October 1, 2010
The study investigates the role of tenascin-C (TNC) in spinal cord regeneration using TNC-deficient mice and wild-type controls after spinal cord injury. The findings indicate that TNC deficiency impa...
KEY FINDING: TNC-deficient mice exhibit impaired locomotor recovery after spinal cord injury compared to wild-type mice.
Int J Dev Neurosci, 2010 • October 1, 2010
This study investigates the temporal profile of the P2Y2 nucleotide receptor after spinal cord injury (SCI) in adult female Sprague–Dawley rats, focusing on its role in the pathophysiology response ge...
KEY FINDING: P2Y2 mRNA significantly increased after 2 days post-injury and remained elevated for 28 days.