Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,121-5,130 of 5,401 results
FASEB J., 2004 • February 1, 2004
This study demonstrates the potential of xenotransplantation of characterized OECs into the primate spinal cord, resulting in remyelination of demyelinated axons. The use of HT transgenic pig OECs, mo...
KEY FINDING: Transplantation of HT transgenic pig OECs into demyelinated lesions in the monkey spinal cord resulted in robust remyelination in 62.5% of transplant sites.
Eur Spine J, 2003 • November 19, 2002
This case report describes a 48-year-old man with an intramedullary schwannoma extending from the conus medullaris to T11, causing bilateral lower extremity weakness. Gross total resection of the tumo...
KEY FINDING: Schwann cells can indeed invade the central nervous system, as demonstrated by the presence of an intramedullary schwannoma within the conus medullaris.
PNAS, 2003 • July 22, 2003
This study investigates the impact of glial fibrillary acidic protein (GFAP) and vimentin deficiency on axonal plasticity and functional recovery following spinal cord injury (SCI) in mice. The key fi...
KEY FINDING: Double mutant mice (lacking both GFAP and Vimentin) exhibited significant recovery of locomotor function 5 weeks after spinal cord hemisection.
The Journal of Neuroscience, 2004 • January 14, 2004
This study examined the role of p75NTR in spinal cord regeneration using p75NTR-deficient mice and a p75NTR-Fc fusion molecule. The results showed that neither the deletion of p75NTR nor the administr...
KEY FINDING: p75NTR immunoreactivity was observed in the dorsal horn and medial part of the dorsal column, but not in the CST of normal mice.
The Journal of Neuroscience, 2004 • March 24, 2004
The study reveals that DCC, a netrin-1 receptor, is present both on the neuronal surface and in intracellular pools in embryonic rat spinal commissural neurons. Netrin-1 application leads to a modest ...
KEY FINDING: Netrin-1 modestly increases cell surface DCC without activating PKA, suggesting a PKA-independent mechanism.
CMLS, Cell. Mol. Life Sci., 2004 • January 19, 2004
This study investigates the mechanisms by which olfactory ensheathing cells (OECs) promote axonal regeneration using an in vitro model of axonal injury. The findings indicate that OECs promote neurite...
KEY FINDING: OECs promote neurite sprouting after injury by acting as a physical substrate for growth.
The Journal of Neuroscience, 2004 • May 19, 2004
This study demonstrates that peripheral nerve injury leads to an increased expression of the Nav1.3 sodium channel in second-order spinal sensory neurons. The upregulation of Nav1.3 contributes to the...
KEY FINDING: Peripheral nerve injury upregulates the expression of Nav1.3 in dorsal horn nociceptive neurons, but not in astrocytes or microglia.
The Journal of Neuroscience, 2004 • July 14, 2004
This study demonstrates that a combinatorial approach, using cAMP to stimulate neuronal cell bodies and neurotrophin-3 (NT-3) to stimulate injured axons, can promote axonal regeneration beyond spinal ...
KEY FINDING: Combined delivery of cAMP and NT-3 significantly promoted axonal growth beyond the spinal cord lesion site, more so than either treatment alone.
The Journal of Neuroscience, 2004 • July 21, 2004
The study developed an in vitro assay that mimics the PG gradient phenotype in the glial scar, demonstrating that adult DRGs form dystrophic endings morphologically and behaviorally similar to those i...
KEY FINDING: PGs can lead to growth cone dystrophy and that, surprisingly, supposedly sterile dystrophic endings are extraordinarily dynamic.
The Journal of Neuroscience, 2004 • September 8, 2004
This study investigates the role of L1.1, a homolog of the mammalian recognition molecule L1, in spinal cord regeneration in adult zebrafish. Using a morpholino-based approach, the researchers reduced...
KEY FINDING: Reducing L1.1 protein expression impairs locomotor recovery in adult zebrafish after spinal cord transection.