Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,131-5,140 of 5,401 results
J Comp Neurol, 2004 • October 25, 2004
This study investigates the effects of conditioning lesions (CLs) on axonal regeneration of descending brain neurons in spinal-cord-transected larval lamprey. The researchers found that CLs at 30% bod...
KEY FINDING: Conditioning lesions at 30% body length, with a two-week delay before a test lesion and a four-week recovery period, significantly enhanced axonal regeneration of descending brain neurons.
The Journal of Neuroscience, 2004 • September 29, 2004
This study investigates the potential of olfactory ensheathing cells (OECs) to repair spinal cord injuries. OECs from adult transgenic rats were transplanted into a dorsal spinal cord transection lesi...
KEY FINDING: Transplanted OECs survived within the lesion zone and oriented longitudinally along axons bridging the transection site.
The Journal of Neuroscience, 2004 • September 29, 2004
This study examined gene expression patterns in rat spinal cords after injury, comparing two different rat strains to understand the molecular response to SCI over time (up to 90 days). Microarray ana...
KEY FINDING: A highly orchestrated tissue repair and remodeling repertoire with a prominent cutaneous wound healing signature is conserved between two widely differing rat strains after spinal cord injury.
The Journal of Experimental Medicine, 2004 • October 18, 2004
This study demonstrates that a single neuroinflammatory lesion in the spinal cord induces axonal remodeling at multiple levels within the motor system. The remodeling includes local interneuron sprout...
KEY FINDING: Local interneurons near the spinal cord lesion sprout new connections, indicated by increased expression of c-Jun and GAP43.
The Journal of Neuroscience, 2004 • November 3, 2004
This study investigates the feasibility of using superparamagnetic iron oxide (SPIO)-labeled Schwann cells (SCs) and olfactory ensheathing cells (OECs) for non-invasive tracking via MRI after transpla...
KEY FINDING: SCs and OECs efficiently internalize dextran-coated SPIO from the culture medium by fluid phase pinocytosis.
The Journal of Neuroscience, 2004 • November 10, 2004
This study demonstrates that mice lacking EphA4 exhibit axonal regeneration and functional recovery after spinal cord injury, including improved motor skills. The absence of EphA4 leads to reduced ast...
KEY FINDING: EphA4-deficient mice exhibit axonal regeneration and functional recovery after spinal cord hemisection, including improvements in stride length, grid walking, and grasping ability.
Exp Neurol, 2005 • March 1, 2005
The study examined the response of endogenous oligodendrocyte precursor cells (OPCs) following ethidium bromide (EB)-induced demyelination of the adult rat spinal cord. A robust mobilization of highly...
KEY FINDING: Nkx2.2+/Olig2+ OPCs are recruited to demyelinated lesions but fail to remyelinate axons in regions lacking astrocytes.
Mol Cell Neurosci, 2005 • May 1, 2005
This study demonstrates that transgenic expression of a secreted function-blocking NgR protein has profound effects after SCI, stimulating both CST and raphespinal fiber growth in the injured spinal c...
KEY FINDING: Transgenic mice expressing NgR(310)ecto showed increased CST fiber growth into the caudal spinal cord after dorsal over-hemisection compared to wild-type mice.
Nat Neurosci, 2005 • June 1, 2005
This study investigates the role of XTRPC1, a calcium channel, in neuronal growth cone guidance in Xenopus spinal neurons. The findings demonstrate that XTRPC1 is required for growth cone turning resp...
KEY FINDING: XTRPC1 is required for the proper growth cone turning responses of Xenopus spinal neurons to microscopic gradients of netrin-1, brain-derived neurotrophic factor (BDNF), and myelin-associated glycoprotein (MAG).
Cellular and Molecular Neurobiology, 2005 • April 1, 2005
The study comprehensively screens for genes that change their expression during the brief critical period in development when the neonatal mammalian central nervous system (CNS) loses its capacity to ...
KEY FINDING: The study identified a set of genes that are differentially expressed in regenerating versus non-regenerating spinal cords of neonatal opossums, including novel sequences and genes involved in cell growth, motility, and myelin formation.