Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,081-5,090 of 5,401 results
iScience, 2021 • February 19, 2021
This study provides in vivo evidence showing that repeated EA treatment modulates the cortical circuit to relieve neuropathic pain. The activation of CB1R by EA leads to presynaptic inhibition at GABA...
KEY FINDING: EA treatment reduces both mechanical and thermal hypersensitivity in mice with neuropathic pain, indicating its analgesic effects.
Frontiers in Cellular Neuroscience, 2021 • January 28, 2021
This study provides a comprehensive proteomic and secretomic characterization of human neural stem cells (NSCs) during in vitro differentiation. NSCs were differentiated spontaneously or with trophic ...
KEY FINDING: Substantial protein differences were identified in the early stages of NSC differentiation. More than a third of all the proteins were regulated, including known neuronal and NSC multipotency markers.
Nat Neurosci, 2021 • March 1, 2021
The review addresses the current understanding of reactive astrocytes, their nomenclature, and the challenges in defining their roles in CNS diseases and aging. It critiques the oversimplified binary ...
KEY FINDING: Reactive astrocytes engage in molecularly defined programs involving changes in transcriptional regulation, biochemical, morphological, metabolic, and physiological remodeling, resulting in altered function.
Frontiers in Neuroscience, 2021 • February 1, 2021
This review summarizes the extrinsic and intrinsic mechanisms for central nerve regeneration, especially the roles of non-coding RNAs. After central nerve injury, many non-coding RNAs are expressed di...
KEY FINDING: miRNAs, such as microRNA-125b, can promote axon regeneration after spinal cord injury by influencing pathways like JAK/STAT and reducing apoptosis and inflammation.
Mol Brain, 2021 • February 4, 2021
This study systematically examined the expression pattern of Olig2, a transcription factor, in various cell types throughout the adult mouse brain and spinal cord. The research identified that Olig2 i...
KEY FINDING: Olig2 is universally expressed in oligodendrocytes and oligodendrocyte precursor cells (OPCs) but not in neurons or microglia in the adult mouse CNS.
Open Biol, 2021 • January 21, 2021
This study identifies a specific cell population, SrRCs, that responds to spinal cord injury (SCI) stress and actively participates in neuronal regeneration, primarily composed of radial glia (RGs) an...
KEY FINDING: A specific SCI-induced cell population, SrRCs, involved in neuronal regeneration.
Neural Plasticity, 2021 • February 8, 2021
This pilot study investigated the impact of the rubber hand illusion (RHI) and repetitive transcranial magnetic stimulation (rTMS) on brain connectivity in healthy participants and a patient with spin...
KEY FINDING: There is no difference in connectivity between sham and real TBS or in the effectiveness of RHI.
Oxidative Medicine and Cellular Longevity, 2021 • February 10, 2021
The study found that RXRα inhibits neurite regeneration and functional recovery after spinal cord injury in rats. It demonstrated that RXRα promotes p66shc expression, which impedes neurite regenerati...
KEY FINDING: RXRα agonists inhibit nerve regeneration after spinal cord injury, while RXRα antagonists promote the regeneration of injured neurites and the recovery of motor function in rats.
Front. Aging Neurosci., 2021 • February 9, 2021
This study investigated the role of immune cell infiltration in Parkinson's disease (PD) by analyzing transcriptomic datasets from the substantia nigra of PD patients and healthy controls. The study i...
KEY FINDING: The study identified 10 types of immune cells with significantly different infiltration levels between PD patients and healthy controls, including activated B cells, CD56 bright natural killer cells, and mast cells.
Cell Death & Disease, 2021 • March 12, 2021
This study demonstrates that inhibiting ULK1, a key autophagic protein, using AAV.ULK1.DN promotes axonal regeneration in vitro and in vivo. The study found that AAV.ULK1.DN enhances neurite outgrowth...
KEY FINDING: AAV.ULK1.DN fosters axonal regeneration and enhances neurite outgrowth in vitro.