Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 41-50 of 5,401 results
PLoS ONE, 2011 • July 1, 2011
This study investigates the role of 6-sulphated chondroitins in axonal regeneration using C6ST-1 knockout mice. The researchers examined axon regeneration in both the central and peripheral nervous sy...
KEY FINDING: C6ST-1 knockout mice showed diminished regeneration of nigrostriatal TH-positive axons compared to wild-type animals after CNS injury.
Brain Pathology, 2012 • January 1, 2012
The study characterized the composition and distribution of spinal cord ECM during TMEV infection to identify underlying molecular mechanisms and transcriptional changes. Microarray analysis revealed ...
KEY FINDING: Progressive accumulation of chondroitin sulfate proteoglycans, glycoproteins, and collagens occurred within demyelinated TME lesions, paralleling astrogliosis development.
JoVE, 2011 • July 18, 2011
This protocol combines the DRG injury model with chromatin immunoprecipitation to investigate the transcriptional and epigenetic environment after injury to either the PNS or CNS. The ChIP protocol is...
KEY FINDING: The protocol demonstrates fragmented DNA to a length of approximately 200-1000 bp following sonication.
Mol Nutr Food Res, 2011 • September 1, 2011
Acrolein, an α,β-unsaturated aldehyde, is a ubiquitous pollutant that is also produced endogenously through lipid peroxidation. Acrolein may overwhelm the anti-oxidative systems of any cell by depleti...
KEY FINDING: Acrolein is significantly more toxic than other aldehydes like HNE, causing membrane disruption at much lower concentrations.
J Comp Neurol, 2012 • October 15, 2012
This report describes an increase in sulfated CS-GAG expression in the injury core and in a tight band surrounding it, and a decrease in the number of PNNs and the level of aggrecan and phosphacan in ...
KEY FINDING: TBI resulted in an increase in the CSPGs neurocan and NG2 expression in a tight band surrounding the injury core, which overlapped with the presence of 4-sulfated CS GAGs but not with 6-sulfated GAGs.
Muscle Nerve, 2011 • October 1, 2011
This study used a genome-wide association study (GWAS) approach to identify genetic susceptibility loci in patients with severe statin myopathy compared to a statin-tolerant group. Replication studies...
KEY FINDING: Three SNPs (rs9342288, rs1337512 and rs3857532) in the EYS gene on chromosome 6 are suggestively associated with risk for severe statin myopathy.
Glia, 2011 • December 1, 2011
This study investigates the role of CXCR4 signaling in regulating remyelination by endogenous oligodendrocyte progenitor cells (OPCs) in a viral model of demyelination. The findings suggest that CXCR4...
KEY FINDING: CXCR4 signaling is required for OPCs to mature and contribute to remyelination in response to JHMV-induced demyelination.
Journal of Neuroinflammation, 2011 • August 30, 2011
Successful peripheral axon regeneration is associated with a rapid and efficient inflammatory response that is terminated in due course. Schwann cells and macrophages communicate via cytokine networks...
KEY FINDING: Axon degeneration in the distal nerve instigates subsequent degenerative processes after PNI; however, axon degeneration does not begin immediately.
J Neurosurg Spine, 2011 • December 1, 2011
The authors investigated the feasibility of using injectable hydrogels, based on poly(N-isopropylacrylamide) (PNIPAAm), lightly crosslinked with polyethylene glycol (PEG) or methylcellulose (MC), to s...
KEY FINDING: The scaffolds did not worsen inflammation related to the injury.
Neurotherapeutics, 2011 • September 9, 2011
This review discusses the potential of neurotrophic factors as therapeutic tools for treating spinal cord injury (SCI) by enhancing axonal plasticity and regeneration. The review highlights the mechan...
KEY FINDING: Neurotrophins like NGF, BDNF, and NT-3 can promote the regeneration of specific neuronal populations after SCI. For example, NGF promotes sprouting of cholinergic motor axons, while BDNF supports regeneration of raphaespinal and rubrospinal axons.