Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 31-40 of 5,401 results
Brain Stimul., 2024 • March 7, 2024
The study used intracortical microstimulation (ICMS) to investigate time-order errors (TOEs) in the somatosensory cortex of three human participants with spinal cord injuries. Participants performed a...
KEY FINDING: Systematic biases were observed in amplitude discrimination tasks, with the intensity of the second stimulus often overestimated, and the degree of overestimation depended on perceptual sensitivity.
Cell Mol Neurobiol, 2011 • May 21, 2011
This study investigates the expression and role of ephrinA ligands, particularly ephrinA1, after spinal cord injury (SCI) in adult rats. The researchers found that ephrinA1 mRNA levels were significan...
KEY FINDING: EphrinA1 was the only ligand whose mRNA levels were significantly altered after SCI.
J Comp Neurol, 2011 • December 15, 2011
This study investigates the assembly properties of lamprey neurofilaments (NFs) and their expression following spinal cord transection. The findings challenge the previous assumption that lampreys pos...
KEY FINDING: Lamprey NFs require multiple subunits for assembly, including L-NFL (a lamprey NFL homolog) and NFM-like subunits (NF95, NF132, and NF180).
Frontiers in Neurology, 2011 • May 17, 2011
This study investigates the expression of Activating Transcription Factor 3 (ATF3) after nerve injuries in rats and humans, aiming to determine if ATF3 induction correlates with regenerative response ...
KEY FINDING: ATF3 expression is up-regulated in a distance-dependent manner after nerve lesions. The closer the lesion is to the cell body, the earlier ATF3 is detected.
Cell Mol Neurobiol, 2011 • June 1, 2011
This study investigates the effect of ChABC on axon regeneration after spinal cord injury in rats. The researchers found that ChABC treatment decreased NG2 expression and enhanced GAP-43 expression at...
KEY FINDING: Multiple injections of ChABC decreased NG2 expression at the lesion site at 5 and 7 days after injury compared to vehicle-treated rats.
The Journal of Spinal Cord Medicine, 2011 • April 1, 2011
This study reports on a series of eight patients who underwent nerve allograft transplantation for brachial plexus injuries. The goal was to assess the safety and efficacy of using cadaveric or living...
KEY FINDING: Seven out of eight patients showed signs of nerve regeneration after allograft transplantation, indicated by return of sensory and motor function or a migrating Tinel’s sign.
CNS Drugs, 2011 • July 1, 2011
Repair of the central nervous system (CNS) constitutes the integral part in treating neurologic diseases and plays a crucial role in restoring CNS architecture and function. In this review, we discuss...
KEY FINDING: The major challenges of CNS repair include neurodegeneration and pathological obstacles impeding neural cell growth after CNS injury.
Nat Neurosci., 2011 • August 1, 2011
The study investigates the role of Axin2, a Wnt signaling target, in newborn brain injury and remyelination. It finds Axin2 expression in immature oligodendrocyte progenitor cells (OLP) within white m...
KEY FINDING: AXIN2 mRNA marks OLP in human neonatal white matter injury
Journal of Neuroinflammation, 2011 • July 6, 2011
This study investigates whether GSNO promotes neurorepair processes by reducing peroxynitrite levels and oxidative injury in rats after TBI. The results demonstrate that GSNO reduces peroxynitrite, pr...
KEY FINDING: GSNO treatment reduced peroxynitrite, lipid peroxides/aldehydes, BBB leakage, inflammation, and edema in the short term (4-48 hours) following TBI in rats.
PLoS ONE, 2011 • June 30, 2011
The study aimed to enhance the survival and neuronal differentiation of transplanted NSPCs in spinal cord injured rats using dbcAMP. Pre-treating NSPCs with dbcAMP before transplantation significantly...
KEY FINDING: NSPC survival was highest in the group pre-treated with dbcAMP, showing approximately 80% survival at both 2 and 6 weeks after transplantation.