Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 371-380 of 5,401 results
Neural Regeneration Research, 2014 • February 1, 2014
This study explored the use of amino-functionalized multi-walled carbon nanotubes (MWCNTs) to deliver nerve growth factor (NGF). The researchers prepared MWCNTs-NGF complexes and assessed their physic...
KEY FINDING: Amino functionalization improves the dispersibility of carbon nanotubes-nerve growth factor complexes.
Neural Regen Res, 2014 • February 1, 2014
This review discusses the extracellular matrix (ECM) and its role in axonal outgrowth regulation following central nervous system (CNS) injury, focusing on proteoglycan structure and function. It high...
KEY FINDING: Specific receptors for CSPGs have been identified, suggesting that CSPGs inhibit axon growth through multiple mechanisms, opening new avenues for therapeutic development.
Neural Regen Res, 2014 • February 1, 2014
Proteoglycans (PGs) in the central nervous system play integral roles as “traffic signals” for the direction of neurite outgrowth. The review further describes the methods routinely used to determine ...
KEY FINDING: Proteoglycans (PGs) in the central nervous system play integral roles as “traffic signals” for the direction of neurite outgrowth, influencing regeneration after injury.
Neural Regeneration Research, 2014 • March 1, 2014
The limited axonal growth after central nervous system (CNS) injury such as spinal cord injury presents a major challenge in promoting repair and recovery. Here, we argue that sprouting of uninjured a...
KEY FINDING: Inhibition of Nogo signaling leads to axon sprouting after spinal cord injury. Administration of an antibody that recognizes Nogo-A increased sprouting of the intact CST and functional recovery.
The Journal of Neuroscience, 2014 • September 10, 2014
The study investigated the effects of different spinal cord lesions on corticospinal tract (CST) sprouting in macaque monkeys, focusing on the primary motor (M1) and primary somatosensory (S1) cortex....
KEY FINDING: Following a DRL alone, the corticospinal tract (CST) projections from the primary somatosensory cortex (S1) shrank, while those from the primary motor cortex (M1) remained stable or expanded.
Neural Regeneration Research, 2014 • February 1, 2014
Axon growth is crucial for nervous system development and post-injury recovery. CSPGs and HSPGs, acting like traffic signals, respectively inhibit and promote axon growth. The identification of LAR an...
KEY FINDING: CSPGs and HSPGs have opposite effects on axonal behavior, with CSPGs often acting as repulsive guidance molecules and HSPGs as attractive signals.
Neural Regeneration Research, 2014 • March 1, 2014
This study investigated the effects of puerarin on neural regeneration after sciatic nerve injury in mice. Puerarin was administered at different doses, and its impact on GAP43 expression, muscle atro...
KEY FINDING: Puerarin at middle and high doses significantly up-regulated the expression of growth-associated protein 43 in the L4–6 segments of the spinal cord from mice at 1, 2, and 4 weeks after modeling.
PLoS ONE, 2014 • September 12, 2014
In this study, by incorporating NT-3 into a SF coating, we successfully developed NT-3-immobilized scaffolds (membranes and conduits). Furthermore, 8 weeks after the NSCs were seeded into conduits and...
KEY FINDING: NSC neuronal differentiation was 55.264.1% on the NT-3-immobilized membranes, which was significantly higher than that on the NT-3 free membrane.
Neurobiol Dis, 2015 • January 1, 2015
In this study, we demonstrate that transgenic deletion of LAR increased growth of descending serotonergic axons and CST fibers in reactive scar tissues and caudal spinal cord after SCI. Furthermore, L...
KEY FINDING: LAR deletion increased regrowth of serotonergic axons into scar tissues and caudal spinal cord after dorsal overhemitransection.
Neural Regeneration Research, 2014 • July 1, 2014
Myelin regeneration is critical for treating CNS disorders like MS and SCI, as it restores neurophysiology and protects axons from degeneration. Understanding the mechanisms of remyelination is essent...
KEY FINDING: Myelin regeneration shares similarities with myelin development, involving OPC proliferation, migration, differentiation, and myelination, but remyelinated axons often have thinner myelin sheaths and different nodal domain cytoarchitecture.