Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 161-170 of 5,401 results
Molecular Pain, 2012 • November 7, 2012
This study comprehensively maps the expression of Nav1.7, a key sodium channel, within the pain pathways of rat DRG neurons from peripheral skin terminals to central spinal cord terminals. The finding...
KEY FINDING: Nav1.7 is robustly expressed in small diameter DRG neurons, particularly in both peptidergic and non-peptidergic subpopulations.
Glia, 2013 • September 1, 2013
This study demonstrates that Klk6 signals through PAR1 to regulate oligodendrocyte process stability and extension, myelin gene expression and cell survival in the presence of oligotoxic agents. Eleva...
KEY FINDING: Klk6 mediates loss of oligodendrocyte processes and impedes morphological differentiation of oligodendrocyte progenitor cells (OPCs) in a PAR1-dependent fashion.
Nat Med, 2012 • November 1, 2012
Angiogenesis is a key feature of central nervous system injury. A neovessel-derived signal mediated by prostacyclin triggers axonal sprouting and functional recovery in a mouse model of inflammatory s...
KEY FINDING: Neovessels are formed in perilesional tissue in both inflammatory and traumatic spinal cord injury3,4. In this issue of Nature Medicine, Muramatsu et al.5 use a highly targeted inflammatory injury to the thoracic spinal cord that damages descending corticospinal tract (CST) projections from the brain to model some aspects of human multiple sclerosis.
The Journal of Neuroscience, 2012 • November 7, 2012
Lu et al. (2012) provide an important contribution to the field of neuroscience in demonstrating axonal regeneration following partial and complete cord transection. Perhaps surprisingly, this regener...
KEY FINDING: A combinatorial treatment strategy promoted axonal regeneration in both hemisection and full transection models.
Brain Behav Evol, 2012 • January 1, 2012
The present study examined proliferation and survival of cells following complete spinal cord transection rather than tail amputation in the weakly electric fish Apteronotus leptorhynchus. Spinal tran...
KEY FINDING: Spinal cord transection significantly increased the density of BrdU+ cells along the entire length of the spinal cord at 1 day post transection (dpt), and most newly generated cells survived up to 14 dpt.
Biomaterials, 2013 • February 1, 2013
This study assessed the potential of bioengineered scaffolds to support and guide axonal growth in a severe spinal cord injury model involving complete spinal cord transection in adult rats. The findi...
KEY FINDING: Templated agarose scaffolds support motor axon regeneration into a severe spinal cord injury model.
Brain, 2015 • January 1, 2015
The study investigates the functional role of Olig2 in oligodendrocyte migration and differentiation, both during developmental myelination and under demyelinating conditions. Olig2 overexpression in ...
KEY FINDING: Olig2 overexpression increases the generation of differentiated oligodendrocytes, leading to precocious myelination.
Frontiers in Neuroscience, 2014 • December 16, 2014
The review challenges long-held misconceptions regarding the history and functionality of the blood-brain barrier (BBB), particularly in developing organisms. It highlights misinterpretations of early...
KEY FINDING: Ehrlich did not believe cerebral blood vessels had different permeability than other organs.
Scientific Reports, 2015 • January 19, 2015
This study established a high-throughput platform to investigate astrocyte-substrate interactions, revealing that astrocytes align along microgrooves with elongated and deformed nuclei. The research i...
KEY FINDING: Astrocytes on micropatterned surfaces exhibit changes in cell and nuclear elongation and alignment compared to flat surfaces.
STEM CELLS TRANSLATIONAL MEDICINE, 2012 • October 10, 2012
This review examines the potential of SDF-1 and its receptors to enhance stem cell function in spinal cord repair, highlighting its role in recruiting stem cells, promoting cell survival and maturatio...
KEY FINDING: SDF-1 is crucial for recruiting transplanted stem cells and endogenous progenitor cells to promote functional recovery after spinal cord injury.