Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 171-180 of 5,401 results
Int. J. Mol. Sci., 2012 • October 10, 2012
Successful nerve regeneration after nerve trauma is not only important for the restoration of motor and sensory functions, but also to reduce the potential for abnormal sensory impulse generation that...
KEY FINDING: Transplanted OECs integrate into peripheral nerve transected by crush injury, form peripheral-like myelin on regenerated peripheral nerve fibers and that the OECs are able to signal the regenerated axons to reconstruct nodes of Ranvier (Figure 1A,B) with proper sodium channel (Nav1.6) organization
Int. J. Mol. Sci., 2012 • October 19, 2012
This study examined changes in GDNF protein and mRNA expression levels in the spinal cord after hemi-transection in rats. The key finding was that GDNF protein accumulated in the rostral part of the i...
KEY FINDING: GDNF protein levels increase rapidly in the rostral part of the spinal cord after hemi-transection.
Journal of Biological Chemistry, 2013 • January 18, 2013
This study demonstrates that JNK1 is a key component in Netrin signaling, which is crucial for axon guidance during nervous system development. The researchers found that Netrin-1 activates JNK1 in ne...
KEY FINDING: Netrin-1 increases JNK1 activity, but not JNK2 or JNK3, in the presence of DCC or DSCAM, and expression of both further enhances Netrin-1-induced JNK1 activity in vitro.
PLoS ONE, 2012 • December 7, 2012
This study used genome-scale transcriptional profiling to identify distinct age-dependent expression profiles in rat sensorimotor cortex during acute, subacute and chronic phases of spinal cord injury...
KEY FINDING: Aging significantly alters the cortical transcriptomes triggered by SCI, with little overlap in lesion-regulated genes between young and old animals.
The Journal of Neuroscience, 2012 • December 12, 2012
This study demonstrates that miR-21 expression increases in astrocytes following spinal cord injury (SCI) and plays a crucial role in regulating astrocytic hypertrophy and glial scar formation. Overex...
KEY FINDING: miR-21 expression increases in astrocytes adjacent to the lesion site following spinal cord injury (SCI).
The Journal of Neuroscience, 2012 • December 12, 2012
The study investigated the effects of nerve injury in TDP-43 transgenic mice, which overexpress wild-type or mutant TDP-43, finding that these mice exhibited sustained paralysis, elevated cytoplasmic ...
KEY FINDING: TDP-43 transgenic mice exhibited sustained elevation of TDP-43 cytoplasmic levels in motor neurons after nerve crush, delaying relocalization to the nucleus.
JOURNAL OF NEUROTRAUMA, 2013 • February 1, 2013
This study provides a comprehensive quantitative description of motor deficits and compensations from the acute to the late chronic phase after C6 spinal cord hemisection. Permanent impairments were d...
KEY FINDING: A dramatic (50%), immediate and permanent loss of extensor force occurred in the forelimb but not in the hind limb of the injured side.
PLoS ONE, 2012 • December 12, 2012
The study evaluated how surface structures support neurite outgrowth to push distance limits that can be bridged in nerve regeneration, using time-lapse video to monitor growth cone displacement of fl...
KEY FINDING: Surface structure variability enhanced net velocity by guiding growth cone movement.
Korean J Physiol Pharmacol, 2012 • December 1, 2012
This study investigates the therapeutic potential of human mesenchymal stem cells (hMSCs) and a polymer scaffold in promoting functional recovery after spinal cord hemisection in rats. The researchers...
KEY FINDING: Functional recovery was significantly improved in the polymer with hMSC-transplanted group as compared with control at five weeks after transplantation.
Mol Neurobiol, 2013 • June 1, 2013
Human umbilical cord blood (hUCB) is a rich source of multiple stem cells and is easy to harvest and purify. Human UC/UCB-derived cells can differentiate into multiple cell types of neural lineages an...
KEY FINDING: Human UCB and UCB-derived cells can survive in injured sites in animal models of ischemic brain damage and spinal cord injuries, and promote survival and prevent cell death of local neurons and glia.