Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 131-140 of 5,401 results
Exp Neurol, 2012 • October 1, 2012
This review focuses on CSPG-mediated inhibition and CSPG receptors identified recently, as severed axons in adult mammals do not regenerate appreciably after central nervous system (CNS) injury due to...
KEY FINDING: Two members of the LAR phosphatase subfamily, PTPσ and LAR, are functional receptors that bind CSPGs with high affinity and mediate CSPG inhibitory effects.
Journal of Cerebral Blood Flow & Metabolism, 2012 • August 1, 2012
This study investigates the role of pericytes in the blood–spinal cord barrier (BSCB). It demonstrates that pericyte coverage and number are reduced in spinal cord capillaries compared to the brain, p...
KEY FINDING: Spinal cord capillaries, especially in the anterior horn, have fewer pericytes compared to brain capillaries in wild-type mice.
Cell Cycle, 2012 • September 1, 2012
The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in multiple cellular functions, such as cell metabolism, proliferation and survival. SCI involves multiple pathophysi...
KEY FINDING: Inhibition of mTOR reduces cell death in damaged neural tissue following SCI.
PNAS, 2012 • September 4, 2012
This study investigates the role of Wnt signaling in limiting the regenerative potential of sensory axons in the spinal cord following a conditioning lesion. The research demonstrates that blocking Wn...
KEY FINDING: Peripheral conditioning injury induces the expression of the repulsive Wnt receptor Ryk in sensory neurons.
Biomaterials, 2012 • November 1, 2012
The study details the fabrication of gelatin tubes and membranes for spinal cord repair, focusing on improving mechanical properties and biocompatibility. In vitro studies showed that the gelatin memb...
KEY FINDING: Gelatin membranes with rhBDNF improved Schwann cell adhesion, alignment, and proliferation.
PLoS ONE, 2012 • August 13, 2012
This study investigates the potential neuroprotective effects of G-CSF on synaptic elements related to spinal alpha-motoneurons following sciatic nerve axotomy in MDX mice, an animal model for Duchenn...
KEY FINDING: G-CSF treatment led to a greater preservation of synaptic inputs after injury in MDX mice compared with untreated and placebo groups.
Frontiers in Neurology, 2023 • August 9, 2023
This review was based on 7 studies that met the inclusion criteria. Among four out of these seven studies, participants with cSCIs demonstrated significant improvements in UL function, strength, grasp...
KEY FINDING: Four out of seven studies demonstrated statistically significant improvements in outcome measurements on UL function and strength after RT.
Biomaterials, 2014 • May 1, 2014
The study identifies PTEN antagonist peptides (PAPs) that selectively block PTEN, a negative regulator of axon growth, by targeting its critical functional domains. Systemic administration of PAPs aft...
KEY FINDING: Systemic administration of PTEN antagonist peptides (PAPs) stimulated the growth of descending serotonergic fibers in the caudal spinal cord of adult mice after dorsal over-hemisection injury.
JOURNAL OF NEUROTRAUMA, 2013 • February 1, 2013
This study investigated the effects of sialidase and chondroitinase ABC (ChABC), alone and in combination, on recovery from spinal cord contusion injury in rats. The enzymes were infused for 2 weeks t...
KEY FINDING: Sialidase treatment alone resulted in significantly increased hindlimb motor function, evidenced by higher BBB scores and fewer stepping errors.
Neurotherapeutics, 2012 • August 31, 2012
This study investigates the therapeutic potential of the sigma-1R agonist PRE-084 in the SOD1G93A mouse model of ALS. The results demonstrate that PRE-084 administration significantly improves motor n...
KEY FINDING: PRE-084 administration from 8 weeks of age improved the function of MNs, which was manifested by maintenance of the amplitude of muscle action potentials and locomotor behavior, and preserved neuromuscular connections and MNs in the spinal cord.