Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 121-130 of 5,401 results
BMC Neuroscience, 2012 • June 6, 2012
The study aimed to assess the impact of vascular endothelial growth factor (VEGF) gene therapy on musculocutaneous nerve (MCN) reinnervation following end-to-end (ETE) or end-to-side (ETS) neurorrhaph...
KEY FINDING: Plasmid phVEGF transfection increased VEGF protein levels in Schwann cells of the MCN stumps.
Neural Development, 2012 • June 8, 2012
This study investigates the role of sulfation in spinal cord neural precursor cell (NPC) biology using sodium chlorate (NaClO3), a sulfation inhibitor. NaClO3 treatment affected cell cycle progression...
KEY FINDING: Addition of sodium chlorate to spinal cord neural precursor cell cultures affected cell cycle progression accompanied by changed extracellular signal-regulated kinase 1 or 2 activation levels.
The Journal of Neuroscience, 2012 • June 13, 2012
This study investigated the efficacy of combinatorial treatments in promoting motor axonal regeneration after partial and complete spinal cord transections in rats. The treatments included cAMP inject...
KEY FINDING: Combinatorial treatment with cAMP injections, bone marrow stromal cell grafts, and BDNF gradients resulted in motor axon regeneration beyond both C5 hemisection and T3 complete transection sites in rats.
PLoS ONE, 2012 • June 6, 2012
The study aimed to identify PNS genes that could enhance the regenerative ability of CNS neurons by promoting neurite growth on inhibitory substrates. A high-content screen of over 1100 PNS genes in c...
KEY FINDING: Several known growth associated proteins potentiated neurite growth on laminin.
PLoS ONE, 2012 • June 20, 2012
This study demonstrates that intravenous administration of MSCs improves functional recovery in rats after spinal cord injury. The beneficial effects of MSCs are likely mediated by paracrine mechanism...
KEY FINDING: Intravenously grafted MSCs induced an early improvement in open field and grid navigation scores in rats with spinal cord injuries.
Exp Neurol, 2012 • September 1, 2012
This study investigates the use of a herpes simplex virus (HSV) vector to deliver the C3 transferase (C3t) gene into dorsal root ganglion (DRG) neurons to promote axonal regeneration after cervical ro...
KEY FINDING: HSV vector vC3t produces C3 transferase (C3t) in vitro and in vivo, inhibiting Rho GTPase activity in DRG neurons.
Surgical Neurology International, 2012 • May 31, 2012
This work suggests that Cx43 plays an important role in secondary inflammatory responses after spinal cord injury. With future research, Cx43 may be able to be targeted with an inhibitor and a neuropr...
KEY FINDING: The researchers found that ATP levels, astrogliosis, and microglia activation were reduced in the KO mice lacking Cx43. Furthermore, the researchers assessed functional recovery of the mice by measuring compound action potentials (CAPs). They found that Cx43 KO mice exhibited improved preservation of spinal cord conduction than CX43 WT mice after spinal cord injury.
Molecular Neurodegeneration, 2012 • July 13, 2012
This study investigates the role of bone marrow-derived cells (BMMCs) and fibroblast growth factor-2 (FGF-2) in promoting glial cell proliferation during peripheral nerve regeneration after sciatic ne...
KEY FINDING: Bone marrow-derived cell treatment induces an increase in the expression of FGF-2 in the sciatic nerve, dorsal root ganglia and the dorsolateral (DL) region of the lumbar spinal cord (LSC) in a model of sciatic nerve transection.
Ann Neurol, 2012 • August 1, 2012
This study investigates the role of NFIA in oligodendrocyte development and remyelination, finding it expressed in OLPs but not mature OLs. Functional studies show NFIA suppresses OLP differentiation ...
KEY FINDING: NFIA is expressed in oligodendrocyte progenitors (OLPs) but not in differentiated oligodendrocytes during mouse embryonic development, and this pattern is conserved in human neonatal hypoxic-ischemic encephalopathy (HIE) and multiple sclerosis (MS) lesions.
PNAS, 2012 • July 24, 2012
This study examines the regeneration of the central and peripheral nervous systems during axolotl tail regeneration, focusing on the origin of dorsal root ganglia (DRG), Schwann cells, and melanophore...
KEY FINDING: The correct number and spacing of dorsal root ganglia (DRG) are regenerated after tail amputation in axolotls.