Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 111-120 of 5,401 results
Mol Cell Neurosci, 2012 • June 1, 2012
This study investigates the role of PlexinA2 in limiting axonal growth and recovery after CNS injury. It finds that PlexinA2, a receptor for oligodendrocyte-derived Sema6A, restricts axon growth in th...
KEY FINDING: Outgrowth from adult PlexinA2-/- neurons is not inhibited by Sema6A in vitro.
Cell Mol Neurobiol, 2012 • May 10, 2012
This study investigates the mechanism by which neural stem cell (NSC) transplantation improves functional outcomes after spinal cord injury (SCI) in rats. The study found that NSC transplantation impr...
KEY FINDING: Transplantation of NSCs significantly improved hindlimb locomotor functions in adult rats subjected to transection of the spinal cord.
Brain and Behavior, 2012 • January 3, 2012
This study examined Gpnmb expression in the CNS of adult rats under normal and inflammatory conditions, finding Gpnmb mRNA expression in several brain regions and the spinal cord. Immunohistochemical ...
KEY FINDING: Gpnmb mRNA is expressed in the cerebrum, cerebellum, brain stem, and spinal cord of normal adult rats.
International Journal of Nanomedicine, 2012 • April 13, 2012
The study combines PLGA conduits and neurotrophin-3 (NT-3) to generate NT-3-loaded PLGA carriers in vitro, showing stable NT-3 release for up to 4 weeks. Coseeding NSCs and SCs into NT-3-releasing sca...
KEY FINDING: NT-3-loaded PLGA carriers stably release bioactive NT-3 for up to 4 weeks.
The Journal of Neuroscience, 2012 • May 23, 2012
The study investigates the roles of kindlin-1 and kindlin-2 in axon growth and regeneration, focusing on integrin activation and signaling. Kindlin-1 overexpression enhances integrin activation, promo...
KEY FINDING: Kindlin-2 is present in the nervous system, whereas Kindlin-1 is not naturally expressed.
PLoS ONE, 2012 • May 22, 2012
This study investigated the gene expression differences between wild-type and EphA4 knockout mice following spinal cord injury to understand the mechanisms underlying functional recovery. Microarray a...
KEY FINDING: EphA4 knockout mice show altered expression of genes related to inflammation following spinal cord injury, specifically an attenuated expression of inflammatory genes.
J Physiol, 2012 • May 28, 2012
The study presents a novel glass window implantation method for chronic in vivo spinal cord imaging in mice, enabling repeated, high-resolution microscopy without repeated surgeries. The implanted win...
KEY FINDING: Implanted glass windows stabilize the spinal cord, reduce motion artifacts, and remain clear for extended periods.
The Journal of Neuroscience, 2012 • May 30, 2012
This study investigates the role of Fgf signaling in spinal cord regeneration in zebrafish, focusing on glial cell behavior. Unlike mammals, zebrafish glia form a bridge across the injury site, which ...
KEY FINDING: Following spinal cord injury in zebrafish, glial cells proliferate, migrate, and differentiate to form a glial cell bridge, which is crucial for axonal regeneration.
Frontiers in Endocrinology, 2012 • February 7, 2012
This study establishes that DHEA is biosynthesized in the developing ventral neural tube at the time of neurogenesis and cell fate determination. In in vitro models, DHEA modulated the induction of ex...
KEY FINDING: DHEA induces the expression of class II protein Nkx6.1, motor neuron precursor Olig-2, and definitive motor neuron marker Isl-1/2 in vitro.
JOURNAL OF NEUROTRAUMA, 2012 • August 10, 2012
The study evaluated the efficacy of dissociated predegenerated nerve (dPDN) transplants in promoting spinal cord regeneration and functional recovery in rats with spinal cord injuries, comparing them ...
KEY FINDING: dPDN grafts survive within the injured spinal cord and promote the ingrowth of axons to a similar extent as purified Schwann cell (SC) grafts.