Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 101-110 of 5,401 results
Journal of Neuroinflammation, 2012 • March 15, 2012
This study investigates the role of ADAMTS-4, a proteoglycan-degrading enzyme, in promoting functional recovery after spinal cord injury (SCI). The research demonstrates that ADAMTS-4 can degrade CSPG...
KEY FINDING: ADAMTS-4 degrades endogenous CSPGs like brevican, neurocan, and phosphacan, reversing their inhibition of neurite outgrowth in vitro.
JBC, 2012 • May 18, 2012
The neural cell adhesion molecule L1 plays crucial roles during development of the nervous system, such as neuronal migration and survival, axon outgrowth and fasciculation, and myelination, but it is...
KEY FINDING: L1 stimulation leads to the generation of a 70-kDa transmembrane fragment that is translocated to the nucleus.
Glia, 2012 • May 1, 2012
This study investigates the effects of implanting polysialic acid (PSA)-modified Schwann cells (SCs) into a spinal cord contusion injury model in rats. The results indicate that PSA modification enhan...
KEY FINDING: PST-GFP SCs migrated significantly farther from the injury site compared to GFP SCs, extending up to 4.4 mm into the host tissue.
J Chem Neuroanat, 2012 • May 1, 2012
This study describes the spatial distribution of PlexinA4 in the rat spinal cord, as well as its co-expression with markers of motor neurons throughout the adult spinal cord. Evidence of PlexinA4 expr...
KEY FINDING: PlexinA4 immunolabeling was found in neurons in both dorsal and ventral horns of the spinal cord, with more PlexinA4 positive neurons in the ventral horn.
Exp Neurol, 2012 • June 1, 2012
This study investigates the roles of neuronal (NRP) and glial (GRP) precursors in overcoming the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs) after spinal cord injury (SCI). The res...
KEY FINDING: Neurons derived from NRPs are intrinsically less sensitive to CSPGs, enabling them to extend axons across CSPG-rich areas.
Cell Tissue Res., 2012 • July 1, 2012
Axonal regeneration in the adult CNS is inhibited by multiple mechanisms, including inhibitory molecules, glial and inflammatory reactions, and insufficient stimulation of axonal growth. Neurotrophic ...
KEY FINDING: Combining neurotrophic factors with cell transplantation can promote robust axonal growth into cellular transplants.
PNAS, 2012 • May 8, 2012
The study addresses the failure of axon regeneration in the CNS due to a developmental decline in the intrinsic ability of neurons to extend axons, focusing on the transcription factor KLF7. To overco...
KEY FINDING: VP16-KLF7 effectively promotes neurite outgrowth and displays enhanced expression compared to wild-type KLF7 in dissociated neurons.
Journal of Brachial Plexus and Peripheral Nerve Injury, 2012 • April 30, 2012
The present study indicates a discrepancy between functional recovery evaluated by toe spreading and structural regeneration analyzed by retrograde tracing. Toe spreading of ANT animals improved signi...
KEY FINDING: ANT animals did not reach pre-surgical levels of toe spreading at the end of the observation period.
Spinal Cord Series and Cases, 2023 • July 12, 2023
This article is a correction to the legend of Fig. 3 in a previously published case report. The correction clarifies the effect of autogenic biofeedback training on gastric electrical activity in a pa...
KEY FINDING: The participant with SCI's gastric electrical activity decreased and its variability decreased, becoming progressively closer to the normal range of 3 cycles per minute after autogenic biofeedback training.
Journal of Cerebral Blood Flow & Metabolism, 2012 • May 2, 2012
This review discusses the principles of neuroinflammation, focusing on the role of microglia and common neurologic disease mechanisms. It also highlights the molecular targets currently used and explo...
KEY FINDING: Microglial activation, a key component of neuroinflammation, can be imaged using TSPO-targeting tracers in various neurological diseases.