Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 711-720 of 730 results
International Journal of Molecular Sciences, 2021 • March 9, 2021
This study investigates the effects of montelukast (MTK), a leukotriene receptor antagonist, on neuroinflammation and cognition in 5xFAD mice, a model for Alzheimer's disease (AD). The results showed ...
KEY FINDING: MTK treatment modulated glial activation and neuroinflammation pathways in 5xFAD mice. The treatment increased Tmem119+ microglia and downregulated genes related to AD-associated microglia.
PNAS, 2001 • December 18, 2001
This study investigates the effect of posttraumatic immunization with a peptide derived from Nogo-A (p472) on recovery from spinal cord injury in rats. The study found that immunization with p472 redu...
KEY FINDING: Posttraumatic immunization with p472, a peptide derived from Nogo-A, substantially reduced neuronal degeneration and promoted recovery after incomplete spinal-cord contusion in rats.
PLoS Medicine, 2007 • April 10, 2007
The study investigates the potential of TREM2-transduced myeloid precursor cells to mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis (EAE). Resu...
KEY FINDING: TREM2-transduced myeloid cells migrated to inflammatory lesions in the spinal cord of EAE mice.
Exp Neurol, 2008 • February 1, 2008
Inflammation following SCI has been shown to have both pathogenic and pivotal roles in tissue repair. A challenge for researchers is to learn how to control cross-talk between the nervous and immune s...
KEY FINDING: The inflammatory response in the brain differs from that in the spinal cord in terms of timing, composition, and magnitude.
Neuroscience, 2009 • February 6, 2009
Traumatic SCI triggers autoimmune reactions involving T and B cells, influencing post-traumatic inflammation, neurodegeneration, and repair processes. These lymphocytes are activated by SCI and play s...
KEY FINDING: SCI activates MBP-reactive T cells capable of causing neuroinflammation and transient paralysis in rats, and the frequency of MBP-reactive T cells increases in SCI humans, reaching levels that approximate those seen in MS patients.
The Journal of Neuroscience, 2008 • September 17, 2008
This study demonstrates the critical role of CD11b+ myeloid cells in axon regeneration after neural injury, using a transgenic mouse model for selective cell ablation. The absence of CD11b+ cells lead...
KEY FINDING: Selective ablation of CD11b+ cells impairs axonal regeneration and locomotor function recovery after sciatic nerve injury.
Journal of Neuroinflammation, 2008 • October 15, 2008
The study investigates the effect of TMEV infection on inflammation and neurogenesis in the SVZ, a key area for brain repair. Results indicated that forebrain CD45+ cell activation precedes spinal cor...
KEY FINDING: CD45+ cell activation occurs early in the forebrain after TMEV infection, with the SVZ showing the most consistent activation.
The Journal of Neuroscience, 2009 • March 25, 2009
This study demonstrates that activated macrophages can simultaneously promote axon regeneration and neurotoxicity in the CNS. Zymosan-activated macrophages (ZAMs) initially enhance axon growth towards...
KEY FINDING: Activated macrophages (ZAMs) increase axon growth towards macrophage foci in the spinal cord, indicating a pro-regenerative effect.
J. Anat., 2009 • June 24, 2009
This study investigated the effect of cyclosporin A (CsA) on functional recovery and the cellular environment following spinal cord contusion injury in rats. CsA was administered to rats after a moder...
KEY FINDING: CsA treatment resulted in a short-term functional improvement at 3 weeks post-injury in the left hindlimbs of rats.
JOURNAL OF NEUROTRAUMA, 2009 • December 1, 2009
This study investigates the efficacy of FTY720, an immunomodulatory drug, in reducing inflammation and promoting functional recovery in a rat model of spinal cord injury (SCI). The hypothesis is that ...
KEY FINDING: FTY720 treatment significantly reduced the infiltration of CD4+ T-helper cells and CD8+ cytotoxic T-cells into the spinal cord lesion site after injury, as shown by flow cytometry.