Genetics Research

KEY FINDING: Conventional SCS transiently attenuated mechanical hypersensitivity in rats with chronic constriction injury (CCI) of the sciatic nerve.

KEY FINDING: Cur-NPs exhibit pH/temperature dual-sensitivity, enabling smart responsive release of curcumin in the inflammatory microenvironment after SCI, thus improving curcumin bioavailability.

KEY FINDING: 2 Hz EA significantly down-regulated the levels of BDNF and TrκB mRNA and protein expression in the spinal cord of SNI rats, along with ameliorating mechanical hypersensitivity.

KEY FINDING: Ferroptosis is linked to spinal cord injury (SCI) in animal models. Inhibiting ferroptosis shows promise in promoting neurological function recovery after SCI.

KEY FINDING: MiR-30b promotes primary sensory neuron axon growth in vitro by targeting and degrading sema3A mRNA.

KEY FINDING: Mitochondrial protein acetylation, particularly through enzymes like GCN5L1 and Sirt3, plays a significant role in neuronal activity and the pathophysiology of cerebral injury. Sirt3, for example, regulates processes such as mPTP opening, mitochondrial dynamics, and mitophagy, protecting mitochondrial function and preventing neuronal death in ischemic stroke.

KEY FINDING: The total amount of CSPG expression significantly increased with time after spinal cord injury, but locomotor training did not affect CSPG expression.

KEY FINDING: TRESK expression is upregulated in both dorsal and ventral neurons of the spinal cord following SCI, with significant increases observed at acute time points (6, 24, and 48 hours) post-injury.

KEY FINDING: Wnt5a and miRNA200b-3p promote NSC differentiation into neurons, with Wnt5a upregulating miRNA200b-3p expression through the MAPK/JNK pathway.

KEY FINDING: The combination of USW and HUC-MSCs significantly improved motor function in SCI rats, with USW playing a more prominent role.