Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 651-660 of 1,773 results
International Journal of Molecular Sciences, 2020 • March 30, 2020
This study evaluated the analgesic effects of spinal cord stimulation (SCS) on neuropathic pain following spared nerve injury (SNI) in rats, focusing on the role of microglial activation and neuronal ...
KEY FINDING: SCS and minocycline both reduced plantar mechanical hypersensitivity in rats after spared nerve injury (SNI), indicating a reduction in pain sensitivity.
J Cell Mol Med, 2020 • May 1, 2020
This study demonstrates that polydatin (PD) enhances the neuronal differentiation of bone marrow mesenchymal stem cells (BMSCs) both in vitro and in vivo, particularly promoting their differentiation ...
KEY FINDING: PD markedly facilitated BMSC differentiation into neuron-like cells by activating the Nrf2 pathway and increased the expression of neuronal markers in the transplanted BMSCs at the injured spinal cord sites.
Neurosci. Bull., 2020 • April 18, 2020
This study investigates the role of SOCS3 in spinal cord regeneration in geckos, focusing on its impact on inflammation mediated by GM-CSF and IFN-c. The researchers found that SOCS3 expression is upr...
KEY FINDING: Severing the gecko spinal cord did not evoke an inflammatory cascade except for an injury-stimulated elevation of the granulocyte/macrophage colony-stimulating factor (GM-CSF) and interferon gamma (IFN-c) cytokines.
Pain Research and Management, 2020 • April 10, 2020
This study investigates the effect of 2 Hz electroacupuncture (EA) on neuropathic pain in rats with spared nerve injury (SNI), focusing on the role of interferon regulatory factor 8 (IRF8) and CX3CRl ...
KEY FINDING: Spared nerve injury (SNI) significantly increased spinal IRF8 and CX3CRl mRNA and protein expression in rats.
International Journal of Molecular Sciences, 2020 • April 30, 2020
This systematic review examines the potential benefits of Actovegin® in treating ischemic stroke, focusing on its pleiotropic actions on injury pathways. The review highlights Actovegin®'s actions in ...
KEY FINDING: Actovegin® improves tissue oxygen and glucose consumption and energy production, especially in the hippocampus, an area linked to learning and memory.
Scientific Reports, 2020 • May 22, 2020
In five patients with acute, severe thoracic traumatic spinal cord injuries (TSCIs), American spinal injuries association Impairment Scale (AIS) grades A–C, we induced cord hypothermia (33 °C) then re...
KEY FINDING: Cooling did not affect cord physiology (ISP, SCPP), but markedly altered cord metabolism and markedly reduced cord inflammation.
Cells, 2020 • May 25, 2020
This study aimed to examine changes in neuronal DNA methylation status after SCI and to determine whether modulation of DNA methylation with ascorbic acid can enhance neuronal regeneration or function...
KEY FINDING: SCI induces alteration of 5mC and 5hmC Levels in the Brain Motor Cortex. The intensity of 5hmC was significantly higher in the SCI group than in the control group at 1 day (acute stage) and 1 week after injury.
Molecular Medicine Reports, 2020 • April 22, 2020
The study investigated the effects of electroacupuncture (EA) on microRNA (miRNA) expression profiles in spinal cord injury (SCI) rats to understand the potential mechanisms involved in SCI recovery. ...
KEY FINDING: Electroacupuncture (EA) treatment improved hindlimb motor function in spinal cord injury (SCI) rats, as indicated by higher Basso, Beattie and Bresnahan (BBB) scores.
International Journal of Molecular Sciences, 2020 • November 24, 2020
The study investigates the combined effect of epidural electrical stimulation (EES) and cell-mediated triple gene therapy on spinal cord injury (SCI) in pigs. The gene therapy involved delivering vasc...
KEY FINDING: Treated pigs showed increased PTIBS scores, indicating improved motor function in hind limbs, and demonstrated vocal and motor reactions during skin pinch tests.
Cell Death & Disease, 2020 • July 23, 2020
This article is a correction to a previously published paper in Cell Death & Disease. The original publication had an error where Figure 6 was displayed incorrectly. The correction replaces the incorr...
KEY FINDING: The original article had an error in Figure 6.