Genetics Research

KEY FINDING: Iskandar et al. found that after injury to somatosensory axons in rodents, there was an increase in the expression of the α-isoform of folate receptor 1 (FOLR1).

KEY FINDING: Spinal cord and peripheral nerve injury induces the expression of the high-affinity folate receptor Folr1, but not the low-affinity reduced folate carrier Rfc1.

KEY FINDING: Mice lacking N-acetylglucosamine 6-O-sulfotransferase-1 (GlcNAc6ST-1), and thus deficient in keratan sulfate, exhibit significantly better motor function recovery after spinal cord injury, as measured by footfall tests, footprint tests, and Basso mouse scale locomotor scoring.

KEY FINDING: GsMTx4, a peptide inhibitor of mechanosensitive ion channels, enhances neurite outgrowth from PC12 cells in the presence of NGF in a dose-dependent manner.

KEY FINDING: P2Y2 mRNA significantly increased after 2 days post-injury and remained elevated for 28 days.

KEY FINDING: GFAP expression in the spinal cord increased after transection, peaking at 3 days, then gradually decreasing.

KEY FINDING: SCI results in increased expression of miR Let-7a and miR16.

KEY FINDING: During development, loss of PTEN in oligodendrocytes leads to excessive myelin formation (hypermyelination).

KEY FINDING: AQP1 is expressed in olfactory ensheathing glia (OEG) in both peripheral and central olfactory structures.

KEY FINDING: Zebrafish foxj1a, but not foxj1b, was rapidly induced in response to epithelial distension and stretch, kidney cyst formation, acute kidney injury, and crush injury in spinal cord cells.