Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,751-1,760 of 1,773 results
Journal of Biological Chemistry, 2010 • January 8, 2010
The study identifies FM19G11 as a novel HIF inhibitor that selectively targets HIF proteins without significant cytotoxicity. FM19G11 promotes oligodendrocyte differentiation under hypoxic conditions ...
KEY FINDING: FM19G11 inhibits HIF1α and HIF2α protein accumulation in human tumor cell lines and stem cells from rodents and humans.
JBC Papers in Press, 2009 • November 9, 2009
This study investigates the role of neuronal Nogo-A in axonal regeneration, finding that its expression increases after axonal injury and exposure to myelin. The research demonstrates that disrupting ...
KEY FINDING: Neuronal Nogo-A expression increases after axonal injury and exposure to myelin.
PLoS ONE, 2009 • December 3, 2009
This study investigates the mechanism by which olfactory ensheathing cells (OECs) migrate to the glial scar after spinal cord injury (SCI) in rats. The research found that reactive astrocytes in the g...
KEY FINDING: Glial scar tissue and reactive astrocyte-conditioned medium promote OECs migration in vitro.
JOURNAL OF NEUROTRAUMA, 2010 • March 1, 2010
The study examined molecular changes in the cervical spinal cord of rhesus monkeys after traumatic brain injury (TBI), focusing on long-term effects up to 12 months post-lesion. Key findings include i...
KEY FINDING: There were significant increases in MHC-II and ERK1/2 immunoreactivity in the lateral corticospinal tract (LCST) of the cervical spinal cord up to 12 months post-lesion, indicating long-term microglial activation.
Exp Neurol, 2010 • June 1, 2010
This study investigates the role of EphA4 in astroglial-fibrotic scar formation after spinal cord injury (SCI) using EphA4 mutant mice. The results indicate that EphA4 deletion does not significantly ...
KEY FINDING: EphA4 expression is primarily associated with astrocytes in the spinal cord and neurons in the cerebral cortex before and after SCI.
J Korean Neurosurg Soc, 2010 • January 1, 2010
The study aimed to investigate the molecular biologic characteristics of primary and recurrent herniated discs to understand the similarities and differences in their gene expression profiles. The res...
KEY FINDING: mRNA gene expression of recurrent disc cells showed increased expression of aggrecan, type I collagen, type II collagen, Sox-9, osteocalcin, and alkaline phosphatase compared to primary herniated lumbar disc cells.
BMC Neuroscience, 2010 • February 18, 2010
The study aimed to use RNAi to knock down Semaphorin receptors Npn-1 and Npn-2 in spinal nerve tracts to promote axon regeneration after spinal cord injury. Effective shRNAs were developed to knock do...
KEY FINDING: shRNAs can effectively knock down Npn-1 and Npn-2 expression in neuronal cell lines in vitro using lentiviral delivery.
Neuron, 2010 • March 11, 2010
This study demonstrates that miRNAs, particularly miR-219 and miR-338, are critical regulators of oligodendrocyte differentiation and myelination in the vertebrate CNS. The research shows that miRNAs ...
KEY FINDING: Deletion of Dicer1, an enzyme essential for miRNA processing, in oligodendrocyte lineage cells leads to severe myelination deficits in mice.
PLoS ONE, 2010 • March 16, 2010
This study demonstrates that RNA aptamers can be selected to bind the Nogo-66 receptor (NgR) and compete with myelin-derived inhibitors of axon regeneration for binding to the receptor. Neurite outgro...
KEY FINDING: RNA aptamers can be generated that bind with high affinity to NgR.
Neurosci Bull, 2010 • April 1, 2010
This study investigates the role of PKC in neurite outgrowth of spinal cord neurons in vitro. The researchers found that changes in m/c-PKC activity and PKC-βII expression were significantly correlate...
KEY FINDING: The ratio of membrane-bound PKC activity to cytoplasmic PKC activity (m/c-PKC) and PKC-βII expression in neurites were significantly correlated with neurite outgrowth.