Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,711-1,720 of 1,773 results
The Journal of Neuroscience, 2007 • December 26, 2007
The study investigates the expression pattern and function of Advillin, an actin-binding protein, in the developing mouse nervous system, focusing on its role in somatosensory neurons. Using a novel A...
KEY FINDING: Advillin mRNA is almost exclusively expressed by craniofacial and dorsal root ganglia sensory neurons, with the exception of Me5 and Mo5 neurons.
PNAS, 2008 • January 15, 2008
This study investigates the role of Nogo-66 receptor (NgR) in motor neuron survival, revealing that peptides derived from the Nogo-66 sequence, Pep4 and NEP1-40, can prevent p75NTR-dependent motor neu...
KEY FINDING: NgR, LINGO-1, and p75NTR mRNAs are expressed in cultures of purified embryonic motor neurons and NSC34 cells, indicating that NgR activation could involve p75NTR in this paradigm.
BMC Neuroscience, 2008 • February 24, 2008
This study investigated the expression and function of peripherin in the tuberomammillary (TM) neurons of the mouse hypothalamus, revealing that peripherin is produced by histaminergic neurons in this...
KEY FINDING: Peripherin is expressed in the tuberomammillary neurons of the mouse hypothalamus, specifically within histaminergic neurons.
Neurosci Bull, 2008 • April 1, 2008
This study combined olfactory ensheathing glia (OEG) implantation with ex vivo non-viral vector-based neurotrophin-3 (NT-3) gene therapy to enhance regeneration after thoracic spinal cord injury (SCI)...
KEY FINDING: NT-3 production was seen increased both ex vivo and in vivo in pcDNA3.1(+)-NT3 transfected OEGs.
Cell Proliferation, 2008 • January 1, 2008
The study demonstrates that IL-6 and EGF stimulate proliferation of spinal cord-derived NPCs through distinct signalling pathways, JAK2/STAT3 and MAPK, respectively. Inhibition of JAK2 or EGFR prevent...
KEY FINDING: IL-6 and EGF independently stimulate the proliferation of spinal cord-derived NPCs via the JAK2/STAT3 and MAPK pathways, respectively.
The Journal of Clinical Investigation, 2008 • July 1, 2008
This study demonstrates that human olfactory ensheathing cells/olfactory nerve fibroblasts (hOECs/ONFs) promote neuroplasticity in murine models of stroke by secreting trophic factors and upregulating...
KEY FINDING: hOECs/ONFs secrete trophic factors, including SDF-1α, and upregulate CXCR4 under oxygen glucose deprivation (OGD) conditions, promoting neurite outgrowth of primary cortical neurons.
Glia, 2008 • November 15, 2008
This study introduces a novel in vitro model of the glial scar, generated by combining mechanical trauma and co-culture with meningeal cells using highly differentiated astrocytes. The model effective...
KEY FINDING: Mechanical stretch and co-culture with meningeal cells induced astrocyte reactivity, including stellation, clustering, and GFAP accumulation.
J. Anat., 2008 • July 21, 2008
This study investigates the therapeutic potential of bone marrow stromal cells (BMSCs) for treating cerebral stroke in rats. BMSCs were transplanted into the cerebrum of rats following a transient mid...
KEY FINDING: Transplanted BMSCs survived and migrated to areas around the lesion site in the rat brains.
Neurosci Lett, 2008 • October 10, 2008
The study examined the combined effects of FGF-2 gene therapy and voluntary exercise on axonal regeneration across peripheral nerve gaps in rats. Schwann cells (SCs) were transplanted into nerve gaps,...
KEY FINDING: Exercise for 7 days elevated mRNA levels of regeneration associated proteins (GAP-43 and synapsin I) in lumbar spinal cord and dorsal root ganglia of SC transplanted, in contrast to non-cellular reconstructed rats.
J Cell Sci, 2008 • September 15, 2008
This study demonstrates that specific sulfation in chondroitin sulfate (CS) glycosaminoglycan (GAG) chains mediates neuronal guidance cues and axonal growth inhibition, with chondroitin-4-sulfate (CS-...
KEY FINDING: Chondroitin-4-sulfate (CS-A), but not chondroitin-6-sulfate (CS-C), exhibits a strong negative guidance cue to mouse cerebellar granule neurons, indicating that sulfation at the C4 position of the GalNAc moiety presents a specific negative guidance cue to axons.