Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,701-1,710 of 1,773 results
The Journal of Neuroscience, 2007 • June 13, 2007
This study investigates the effects of inhibiting the epidermal growth factor receptor (EGFR) on recovery from spinal cord injury (SCI) in rats. The researchers used PD168393, a potent EGFR inhibitor,...
KEY FINDING: Treatment with PD168393, an EGFR inhibitor, significantly improved locomotor recovery, as indicated by higher BBB scores and BBB subscores compared to the control group.
The Journal of Neuroscience, 2007 • July 4, 2007
This study demonstrates that Schwann cells (SCs) and olfactory ensheathing cells (OECs) differentially interact with astrocytes, influencing astrocytosis following CNS injury. SC-conditioned media (SC...
KEY FINDING: Schwann cell-conditioned media induces reactive astrocytosis and boundary formation in OEC/astrocyte cocultures, sensitive to FGFR1 inhibition.
The Journal of Neuroscience, 2007 • July 25, 2007
This study investigates the role of ATF3, a transcription factor induced by peripheral nerve injury, in promoting nerve regeneration. The researchers generated transgenic mice that constitutively expr...
KEY FINDING: ATF3 enhances the rate of peripheral nerve regeneration to an extent comparable to a preconditioning nerve injury.
Cell Mol Neurobiol, 2007 • September 19, 2007
The study investigates changes in cAMP levels in the developing opossum spinal cord during the critical period when regeneration stops being possible. Endogenous cAMP levels were measured in tissue ho...
KEY FINDING: A significant decrease in cAMP levels was observed during the period when the opossum spinal cord loses its regenerative capability.
Eur Spine J, 2007 • September 21, 2007
The study aimed to evaluate the efficacy of adenovirus vector-mediated BDNF ex vivo gene transfer to BMSC in adult rats with completely transected spinal cords. The results showed that BMSC transplant...
KEY FINDING: Adenovirus vector-mediated ex vivo gene transfer of BDNF to BMSC enhances axonal regeneration in completely transected spinal cord.
The Journal of Neuroscience, 2007 • September 26, 2007
This study investigated whether transient delivery of growth factors could sustain regenerated axons after spinal cord injury (SCI). The researchers used a tetracycline-inducible system to control BDN...
KEY FINDING: Transient growth factor delivery is sufficient to sustain long-term axonal projections into a site of SCI.
Cell. Mol. Life Sci., 2008 • November 20, 2007
Significant spinal cord regeneration following injury is not observed in any adult higher vertebrates (amniotes), but can occur in some lower vertebrates (anamniotes) such as tailed amphibians and fis...
KEY FINDING: Clearwaters reported regeneration in the embryonic spinal cord, but lack of regeneration and extensive scarring in the postnatal spinal cord.
PLoS ONE, 2007 • November 28, 2007
This study investigates the role of TGF-b signaling in axolotl limb regeneration, highlighting the contrast with TGF-b's role in mammalian wound healing, which often results in scarring. The researche...
KEY FINDING: The full-length cDNA sequence of axolotl TGF-b1 was isolated, revealing high homology with mammalian TGF-b1 sequences.
PPAR Research, 2007 • February 28, 2007
This review discusses the roles of RAR/RXR and PPAR/RXR signaling pathways in physiological reactions after spinal cord injury, highlighting their potential as therapeutic targets. RAR signaling may i...
KEY FINDING: RAR signaling may improve axonal regeneration, influence glial differentiation, and modulate inflammatory reactions after spinal cord injury.
The Journal of Neuroscience, 2007 • December 19, 2007
This study investigates the mechanisms underlying neuromuscular maps by studying the preferential outgrowth of embryonic spinal cord neurites on muscle membranes from different axial positions and exp...
KEY FINDING: Rostral cervical spinal cord neurites prefer to grow on rostral diaphragm membranes, while caudal cervical neurites prefer caudal diaphragm membranes.