Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,681-1,690 of 1,773 results
Nat Neurosci, 2005 • June 1, 2005
This study investigates the role of XTRPC1, a calcium channel, in neuronal growth cone guidance in Xenopus spinal neurons. The findings demonstrate that XTRPC1 is required for growth cone turning resp...
KEY FINDING: XTRPC1 is required for the proper growth cone turning responses of Xenopus spinal neurons to microscopic gradients of netrin-1, brain-derived neurotrophic factor (BDNF), and myelin-associated glycoprotein (MAG).
Eur Spine J, 2006 • November 16, 2005
This study examined glial reactions following spinal cord injury in fetal rats compared to adult rats, focusing on astrocytes and microglia. The findings indicated that fetal rats do not develop scar ...
KEY FINDING: Scar formation was observed in adult rats' spinal cords after injury, but not in fetal rats.
PNAS, 2006 • January 17, 2006
This study demonstrates the role of Cdk5 in nociceptive signaling. It identifies the expression of Cdk5 and its activator p35 in nociceptive neurons and shows that this expression is modulated during ...
KEY FINDING: Cdk5 and p35 are expressed in pain-sensing neurons (nociceptors) within the dorsal root ganglia (DRG), trigeminal ganglia (TG), and spinal cord (SC).
BMC Neuroscience, 2006 • January 12, 2006
The study investigates the expression and function of ZAS3, a zinc finger protein, in the nervous system and its relationship with NF-κB after peripheral nerve injury. Results show that ZAS3 is expres...
KEY FINDING: ZAS3 is expressed in specific regions of the central and peripheral nervous system, including the trigeminal ganglion, hippocampal formation, dorsal root ganglia, and motoneurons.
BMC Neuroscience, 2006 • January 24, 2006
The study investigated the effects of LPS-induced inflammation on the expression of growth-associated genes in corticospinal neurons and the potential for axonal regeneration after spinal cord injury....
KEY FINDING: Application of LPS induced a gradient of inflammation throughout the motor cortex.
The Journal of Neuroscience, 2006 • January 25, 2006
This study investigates the contribution of dorsal progenitors to cortical myelination by ablating Olig2, a key gene for oligodendrocyte specification, in these cells. The results demonstrate that dor...
KEY FINDING: Ablation of Olig2 in dorsal progenitors leads to a near-complete absence of myelination in the cortex during early postnatal stages.
PNAS, 2006 • May 16, 2006
This study investigates the role of Olig genes in the development of NG2 cells, a type of glial progenitor cell in the central nervous system. The researchers found that Olig2, a basic helix–loop–heli...
KEY FINDING: More than 90% of NG2 cells in the brain express Olig2 at prenatal, perinatal, and postnatal stages of development.
The Journal of Neuroscience, 2006 • May 17, 2006
The study compares the gene expression profiles of three OEC populations that differ in their capacity to promote adult axonal regeneration in vitro to identify molecules that OECs use to promote axon...
KEY FINDING: MMP2 and its inhibitor Timp2 are candidate molecules that may promote and inhibit axonal regeneration, respectively. MMP2 was found to be present in medium conditioned by primary and TEG3 OECs, whereas MMP2 was barely detected in OEC Lp conditioned medium.
Cellular and Molecular Neurobiology, 2006 • May 6, 2006
This study aimed to understand the complex mechanisms underlying repair and regeneration after spinal cord injury by examining gene expression changes. Researchers used improved subtractive hybridizat...
KEY FINDING: The study identified 40 differentially expressed genes 4.5 days after spinal cord transection in rats, including 32 known genes and 8 novel genes.
J Neurosci Res, 2006 • August 15, 2006
This study evaluates lentiviral, adenoviral, and retroviral vectors for gene delivery to the spinal cord, focusing on transgene expression and inflammatory responses. Lentiviral vectors provided the m...
KEY FINDING: Lentiviral vectors had the most stable pattern of gene expression, with D15A levels remaining high at 4 weeks after both in vivo and ex vivo delivery.