Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,691-1,700 of 1,773 results
The Journal of Neuroscience, 2006 • July 12, 2006
The study demonstrates that modulation of extracellular matrix components promotes significant axonal regeneration beyond a PN bridge back into the spinal cord. Regenerating axons can mediate the retu...
KEY FINDING: ChABC treatment enhanced axonal regrowth from the PN graft into the spinal cord.
The Journal of Neuroscience, 2006 • July 26, 2006
This study aimed to determine if the absence of Tenascin-R (TNR) has beneficial effects on recovery from spinal cord injury (SCI) in adult mice. The researchers used TNR-deficient mice and wild-type l...
KEY FINDING: TNR-deficient mice showed better recovery in open-field locomotion compared to wild-type mice after spinal cord compression.
J Neurobiol, 2006 • December 1, 2006
This study demonstrates that the mechanism of axon regeneration undergoes a developmental switch between E7 and E14 from strict dependence on F-actin to a greater dependence on microtubule polymerizat...
KEY FINDING: Early embryonic (E7) sensory axons strictly require F-actin for axon maintenance and regeneration, whereas later embryonic (E14) axons can extend even in the absence of F-actin.
Dev Biol, 2007 • January 1, 2007
This study investigates the role of apoptosis in tail regeneration in Xenopus laevis tadpoles. It finds that a specific amount of apoptosis is a required component of normal tail regeneration. The res...
KEY FINDING: Apoptosis is required for tail regeneration in Xenopus tadpoles.
J Biol Chem, 2007 • February 23, 2007
The current study extends our understanding of how myelin inhibitors interact with the NgR family: NgR1 binds three linear segments of Nogo-A as well as MAG and OMgp; mutagenesis defined overlapping N...
KEY FINDING: RTN2 and RTN3 interact with NgR1 with nanomolar affinity, suggesting a role in myelin inhibition of axonal growth.
TheScientificWorldJOURNAL, 2006 • May 5, 2006
The review explores the regenerative capabilities of axolotls, focusing on limb regeneration and its similarities to development and wound healing. It emphasizes the biphasic nature of regeneration, t...
KEY FINDING: Limb regeneration is a biphasic process involving a preparation phase (similar to wound healing) and a redevelopment phase (similar to development).
TheScientificWorldJOURNAL, 2006 • July 7, 2006
Newts possess remarkable regenerative abilities due to dedifferentiation, a process where cells revert to a multipotent state. Molecular pathways, including FGFs, MMPs, and Hox genes, control regenera...
KEY FINDING: Dedifferentiation is crucial for limb regeneration in newts, allowing specialized cells to revert to a pluripotent state.
Comp Biochem Physiol B Biochem Mol Biol, 2007 • June 1, 2007
The study isolated and characterized the axolotl orthologue of NPDC-1, a co-regulatory protein involved in retinoic acid signaling. Axolotl NPDC-1 shares structural and functional similarities with it...
KEY FINDING: Axolotl NPDC-1 mRNA expression peaks late in embryogenesis, coinciding with limb development, a process regulated by retinoic acid.
Neurosci Lett., 2007 • May 11, 2007
The study investigates the role of EphA4 receptor upregulation after spinal cord injury (SCI) in rats, examining its impact on axonal regeneration and nerve conduction. The researchers found that whil...
KEY FINDING: EphA4 protein levels initially decreased after SCI (2 and 4 DPI) and then increased at 7 DPI, with a tendency to further increase at 14 and 28 days.
BMC Developmental Biology, 2007 • May 24, 2007
This study investigates the regeneration of neural crest derivatives, specifically melanophores and spinal ganglia, in the Xenopus tadpole tail after amputation. The findings indicate that melanophore...
KEY FINDING: Cells do not emigrate from the spinal cord during tail regeneration, indicating that a new neural crest is not induced as in embryonic development.