Genetics Research

KEY FINDING: UTX expression increases in endothelial cells following spinal cord injury in mice.

KEY FINDING: GH treatment after KA-induced damage significantly restored the thickness of the inner plexiform layer (IPL) and inner nuclear layer (INL) in the retina.

KEY FINDING: The study successfully generated two c-MycERTAM-derived hOMC populations (PA5 and PA7) through retroviral transduction. These cells incorporated the c-MycERTAM transgene into their genome and expressed the corresponding protein.

KEY FINDING: Six miRNAs (hsa-miR-19b-3p, hsa-miR-192-5p, hsa-miR-25-3p, hsa-miR-19a-3p, hsa-miR-18b-5p, hsa-miR-93-5p) were exclusively repressed in patients with degenerative RCTs compared to controls and chronic tendinopathy.

KEY FINDING: Gdf11 activity acts as a master switch, controlling the change from trunk to tail developmental modes in most vertebrates.

KEY FINDING: Loss of Limk1 promotes spinal motor axon outgrowth, suggesting temporal guidance mechanisms are widely used during development.

KEY FINDING: Salamanders exhibit considerable variation in life history, development, physiology, and morphology, more than other tetrapod groups, including variations in limb morphology and digit number.

KEY FINDING: Hyperactivation of Smo in neural progenitors induces transient ectopic OPC generation and precocious OL differentiation.

KEY FINDING: Pramipexole, a dopamine agonist, was identified as a specific enhancer of zTreg recruitment to injured tissue in zebrafish.

KEY FINDING: LIFR protein and mRNA expression in the spinal cords of normal rat embryos increased with embryonic development from E11 to E17.