Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,521-1,530 of 1,773 results
Cells, 2019 • May 21, 2019
The study established a ventral root crush model in mice to analyze motoneuron loss, glial responses, and synaptic changes. It found that neuronal survival decreased over time in both WT and β2m KO mi...
KEY FINDING: Ventral root crush leads to time-dependent motoneuron loss in both WT and β2m KO mice.
Communications Biology, 2019 • May 17, 2019
This study identifies genes promoting extent of CNS axon regrowth using laser-mediated axon transection with confocal time-lapse imaging. Regrowing wild-type axons initiate multidirectional sprouting ...
KEY FINDING: PHR directs regrowing axons along the pre-lesional trajectory and across the transection site in zebrafish spinal axons.
Journal of Orthopaedic Research, 2020 • June 25, 2019
This study aimed to identify risk factors contributing to the degeneration of rotator cuff tendons, specifically the subscapularis (SSC) tendon, by analyzing tissue samples from patients undergoing ar...
KEY FINDING: Patient age significantly correlates with the expression of MMP-2 and RUNX2 genes in the subscapularis tendon.
The EMBO Journal, 2019 • May 22, 2019
The molecular mechanisms discriminating between regenerative failure and success remain elusive. We found that calcium increases in DRG following a regeneration-competent sciatic but not a regeneratio...
KEY FINDING: HDAC3 inhibition promoted neurite outgrowth on both growth-permissive and inhibitory substrates.
Front. Mol. Neurosci., 2019 • June 28, 2019
This review summarizes the current understanding of lncRNAs and circRNAs in nerve regeneration, focusing on their roles in peripheral nerve injury and spinal cord injury. The review highlights specifi...
KEY FINDING: LncRNAs and circRNAs play a role in both peripheral nerve injury and spinal cord injury, influencing processes such as neurite outgrowth, Schwann cell modulation, astrocyte proliferation, and neuronal survival.
Int. J. Biol. Sci., 2019 • June 2, 2019
This study aimed to determine the key miRNAs to regulate the promotion of spinal cord sensory function recovery by SNCI and clarify the associated pathway in vitro and in vivo to develop an alternativ...
KEY FINDING: miR-155-5p promotes DRG neuron axon growth via the cAMP/PKA pathway.
Frontiers in Genetics, 2019 • July 9, 2019
Here, we summarize recent progress in characterizing neuronal intrinsic and extrinsic chromatin reconfigurations and epigenetic changes triggered by axonal injury that shape neuroplasticity and glial ...
KEY FINDING: Peripheral axotomy of DRG neurons elicits unique chromatin alterations with corresponding transcriptional responses.
Neural Regen Res, 2019 • December 1, 2019
This study investigates the therapeutic effects of wrapping a completely severed common peroneal nerve in rats with amniotic membrane (AM). The results showed that AM significantly improves nerve func...
KEY FINDING: Amniotic membrane wrapping significantly improved the function of the injured nerve, leading to faster recovery of toe spread function and nerve conduction velocity.
Neuron, 2019 • September 25, 2019
The study identifies ADF/Cofilin-mediated actin turnover as a molecular mechanism to induce axon regeneration, mimicking processes during development. Conditioning increases actin dynamics by enhancin...
KEY FINDING: Elevated actin turnover is essential for regenerative growth of axons following a conditioning lesion.
Molecular Neurobiology, 2020 • August 30, 2019
This study investigates the regulation of CNS-specific PPARGC1A transcripts in human neuronal cell lines and a rat model of ischemia. The findings reveal that a GT repeat polymorphism and hypoxia infl...
KEY FINDING: A naturally occurring variable GT repeat polymorphism increases promoter activity in neuronal cell lines.