Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,511-1,520 of 1,773 results
Cellular and Molecular Life Sciences, 2019 • April 30, 2019
This study investigates the expression and distribution of KIF2A, a kinesin protein involved in microtubule depolymerization, following spinal cord injury (SCI) in rats, using different injury models....
KEY FINDING: KIF2A expression progressively increases after SCI, peaking between 10 days and 8 weeks post-injury.
Scientific Reports, 2019 • May 7, 2019
This study investigates the role of epigenetic mechanisms, specifically histone deacetylases (HDACs), in axolotl tail regeneration using a chemical genetic screen. The screen identified several HDAC i...
KEY FINDING: A chemical screen identified 55 chemicals that inhibited axolotl tail regeneration, with histone deacetylase inhibitors (HDACi) being highly represented.
Cells, 2019 • April 30, 2019
The study investigated the transcriptome-wide responses of Il-1β-primed rat Achilles tendon cell-derived 3D tendon-like constructs to high-energy PEMF treatment. RNASeq analysis revealed various biolo...
KEY FINDING: PEMF exposure of Il-1β-treated 3D tendon-like constructs resulted in a change in the expression pattern of approximately 5400 genes.
Stem Cell Reports, 2019 • May 2, 2019
The study investigates the cues that govern the maintenance versus differentiation of human medial ganglionic eminence (MGE) progenitors and explores methods for their large-scale expansion. It identi...
KEY FINDING: WNT/CTNNB1 signaling is essential for maintaining human MGE progenitors in an undifferentiated state.
Adv. Sci., 2019 • February 27, 2019
Here, we introduce a biomimicking aligned fiber platform which allows the delivery of miRs both in vitro and in vivo in a sustained and nonviral manner. The easy incorporation of different miRs into t...
KEY FINDING: Enhanced gene-silencing is achieved in neurons as compared to conventional bolus delivery (p < 0.05).
JOURNAL OF EXTRACELLULAR VESICLES, 2019 • April 14, 2019
The inconsistencies in MSC-sEV research are due to the variability in MSC-sEV preparations from the starting cell source to the final product, coupled with a lack of standardized quality assurance ass...
KEY FINDING: MSC-sEVs should be defined by quantifiable metrics to identify the cellular origin of the sEVs in a preparation.
Front. Cell Dev. Biol., 2019 • April 24, 2019
This study demonstrates that glucocorticoid receptor signaling in ependymal glia acts as a critical negative regulator of functional regeneration in the injured spinal cord. Glucocorticoids limit the ...
KEY FINDING: Glucocorticoids inhibit functional recovery from spinal cord injury by impairing the ability of ependymal glia to support regeneration.
eLife, 2019 • May 9, 2019
This study demonstrates that circulating TGF-b1 promotes oligodendrocyte maturation and remyelination in the CNS. The researchers found that decreasing circulating TGF-b1 levels impairs remyelination ...
KEY FINDING: TGF-b1, which is present in higher levels in the systemic environment, promotes oligodendrocyte maturation.
Scientific Reports, 2019 • May 13, 2019
The study aimed to investigate the influence of heparin on stromal cells derived from bone marrow (BM), umbilical cord (UC), and white adipose tissue (WAT), focusing on cellular uptake, gene expressio...
KEY FINDING: Heparin is internalized by stromal cells in a tissue-dependent manner, with BM- and UC-derived cells internalizing significantly more heparin than WAT-derived cells.
Neural Regen Res, 2019 • September 1, 2019
This study used RNA-Seq technology to investigate the differences in transcriptome levels at different stages after SCI. The results of this study showed that compared with the sham group, the number ...
KEY FINDING: RNA sequencing identified a significant number of differentially expressed genes at 1, 4, and 7 days after spinal cord injury in rats.