Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,501-1,510 of 1,773 results
J Cell Mol Med, 2019 • May 1, 2019
This study investigates the role of Sonic hedgehog (SHH) in motor neuron positioning within the developing chicken spinal cord using in ovo electroporation to misexpress SHH. The results showed that e...
KEY FINDING: Ectopic expression of SHH leads to ventralization in the spinal cord, causing abnormalities in the motor column structure and motor neuron integration.
Communications Biology, 2019 • March 4, 2019
This study investigates the molecular mechanisms underlying the pro-regenerative glial cell response in axolotls after spinal cord injury, focusing on the roles of AP-1 transcription factors and miR-2...
KEY FINDING: Axolotl glial cells upregulate a non-canonical AP-1 complex, AP-1cFos/JunB, after spinal cord injury, unlike mammals where AP-1cFos/cJun is upregulated and promotes glial scar formation.
Frontiers in Neuroscience, 2019 • February 21, 2019
This review discusses the current understanding of adult neurogenesis in mammalian brains, highlighting the differences between rodents, primates, and humans. It emphasizes the limitations of endogeno...
KEY FINDING: Adult neurogenesis is limited in humans compared to rodents, which impacts the brain's ability to self-repair.
Life Science Alliance, 2019 • March 25, 2019
This study successfully established a human SMN2-GFP reporter line for drug screening, which allowed the identification of Z-FA-FMK, a cysteine protease inhibitor, as a potential therapeutic agent for...
KEY FINDING: The study established a human SMN2-GFP reporter line for drug screening, which effectively identified compounds that increase functional SMN protein levels.
Frontiers in Neuroscience, 2019 • March 12, 2019
This study demonstrates that BMSC-EV administration critically improves neuronal regeneration and attenuates nerve cell death, which is beneficial for motor function recovery after SCI. Pericyte migrat...
KEY FINDING: Administration of bone mesenchymal stem cell-derived extracellular vesicles (BMSC-EV) reduced brain cell death, enhanced neuronal survival and regeneration, and improved motor function.
Materials, 2019 • April 1, 2019
The results of the present study suggest that AIMPs are effective indicators for identifying dysfunctional peripheral nerves morphologically. The present study indicated that in dysfunctional peripher...
KEY FINDING: AIMPs are highly expressed during nerve degeneration and their increases likely represent peripheral nerve dysfunction morphologically.
Semin Cell Dev Biol, 2020 • January 1, 2020
This review explores the role of epigenetic regulation in neuronal regeneration, focusing on the neural retina, inner ear, and spinal cord. The review highlights the importance of DNA accessibility, h...
KEY FINDING: Changes in DNA accessibility, histone acetylation, and DNA methylation are key epigenetic elements in neuronal regeneration.
Frontiers in Cellular Neuroscience, 2019 • March 27, 2019
This study investigates the role of pericytes (PCs) in influencing the fate of adult neural stem cells (NSCs) towards oligodendrocyte differentiation, which is crucial for remyelination in multiple sc...
KEY FINDING: Conditioned medium from pericytes (PC-CM) significantly increased the expression of oligodendroglial markers in adult neural stem cells (NSCs).
eNeuro, 2019 • March 28, 2019
The study presents a novel transgenic mouse model, ATF3-CreERT2, for selective genetic editing of injured neurons. The ATF3-CreERT2 line facilitates recombination specifically in axotomized neurons, e...
KEY FINDING: The ATF3-CreERT2 mouse line allows for selective genetic editing of injured neurons after peripheral nerve injury (PNI) and spinal cord injury.
Front. Cell. Neurosci., 2019 • April 12, 2019
This study investigates the electrophysiological properties of adult zebrafish oligodendrocyte progenitor cells (OPCs) to understand their role in spinal cord regeneration. The research demonstrates t...
KEY FINDING: Adult zebrafish OPCs are electrically active and express functional voltage-gated K+ and Na+ channels.