Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,481-1,490 of 1,773 results
Medical Science Monitor, 2018 • December 8, 2018
This study investigated the epigenetic changes, specifically DNA methylation, in a rat model of spinal cord injury (SCI). The researchers performed whole-genome bisulfite sequencing to identify differ...
KEY FINDING: Following SCI, significant histological changes were observed, including cavities, necrotic tissue, and inflammatory cell infiltration. Motor function scores were also significantly reduced in the SCI group compared to the sham group.
Neural Regen Res, 2019 • March 1, 2019
This study investigates the role of ferroptosis, an iron-dependent cell death pathway, in secondary injury following spinal cord injury (SCI) and the potential therapeutic effect of deferoxamine (DFO)...
KEY FINDING: Deferoxamine (DFO) treatment improved hindlimb locomotor function in rats with spinal cord injury (SCI).
Neural Regen Res, 2019 • March 1, 2019
The study investigates the spatio-temporal expression of AIM2 in normal and injured spinal cords of rats after contusive SCI. AIM2 expression increases significantly in the early phase (1 hour to 1 da...
KEY FINDING: AIM2 protein expression significantly increased at 1 hour, 6 hours, and 1 day post-spinal cord injury compared to sham-operated rats.
J. Cell. Mol. Med., 2019 • March 1, 2019
This study introduces and validates a method combining in ovo electroporation and organotypic slice culture to study gene function in the developing chicken central nervous system (CNS). The research ...
KEY FINDING: The study successfully combined in ovo electroporation with organotypic slice culture for the chicken embryonic CNS, enabling the study of exogenous gene functions.
Dev Dyn, 2019 • February 1, 2019
This study demonstrates that reactive oxygen species (ROS) are required for tail regeneration in axolotl embryos. ROS levels increase rapidly after amputation and remain elevated for the first 24 hour...
KEY FINDING: ROS levels increase rapidly following tail amputation in axolotl embryos, peaking within minutes and remaining elevated for 24 hours.
Molecular Brain, 2019 • January 4, 2019
This study examined the pathological changes in the distal spinal cord after complete thoracic SCI in mice, focusing on motor neurons in the lumbar region. Key findings include widespread atrophy in t...
KEY FINDING: The size of the spinal cord decreases not only at the injury site but also in areas both above and below the injury.
Neural Regeneration Research, 2019 • April 1, 2019
This study aimed to investigate the neuroprotective effects of rapamycin on spinal cord injury (SCI) in rats by examining its impact on autophagy and Akt signaling pathways. The results demonstrated t...
KEY FINDING: Rapamycin inhibits mTOR expression and up-regulates Beclin 1 and phosphorylated-Akt expression in injured spinal cord tissue.
Nat Neurosci, 2019 • February 1, 2019
The study identifies RNAs regulated by TDP-43 in human motor neurons, revealing that STMN2 expression declines after TDP-43 knockdown and mislocalization. It demonstrates that STMN2 is essential for a...
KEY FINDING: TDP-43 knockdown in human motor neurons (hMNs) leads to decreased STMN2 expression due to altered splicing.
Nat Neurosci, 2019 • February 1, 2019
This study identifies that TDP-43 regulates the expression of stathmin-2, a neuronal growth-associated factor, and that reduced TDP-43 levels lead to the utilization of a cryptic polyadenylation site ...
KEY FINDING: TDP-43 regulates the expression of stathmin-2, a neuronal growth-associated factor, by binding to sites within the first intron of stathmin-2 pre-mRNA.
Neurospine, 2019 • December 1, 2019
Spinal cord injury (SCI) is a devastating condition with limited regenerative capacity, leading to lifelong disability. Current treatments primarily focus on neurorehabilitation and managing complicat...
KEY FINDING: aFGF has shown promise for neural regeneration in multiple trials, including human and animal experiments, warranting further investigation as a neurotrophic factor.