Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,471-1,480 of 1,773 results
Journal of Orthopaedic Surgery and Research, 2018 • September 28, 2018
This study explored the use of serum chemokine analysis to predict outcomes in non-union patients undergoing Masquelet therapy. The research identified CCL-3 and IFN-γ as potential biomarkers that, wh...
KEY FINDING: CCL-3 expression was significantly higher in non-responders (NR) compared to responders (R) during the study course (p = 0.002).
International Journal of Molecular Sciences, 2018 • October 16, 2018
This editorial provides an overview of current research and potential therapeutic strategies for spinal cord injury (SCI). It highlights the limitations of current treatments and the need for innovati...
KEY FINDING: Combined analysis identified 40 significantly upregulated and 48 significantly downregulated molecules, revealing potential therapeutic candidates not previously considered.
Regen. Med., 2018 • October 22, 2018
The study aimed to determine the bone regenerative potential of a cellular allograft uniquely processed from UCB to optimize high MNC count and to enrich cytokine content. The UCBp-CM elevated prolife...
KEY FINDING: UCBp-CM elevated proliferation and migration rates of mesenchymal stem cells (MSCs) and bone marrow stromal cells.
PNAS, 2018 • October 29, 2018
This study demonstrates that TDP-43 is essential for the proper function of oligodendrocytes, particularly for myelination and cell survival. Deleting TDP-43 in mature oligodendrocytes leads to their ...
KEY FINDING: TDP-43 is indispensable for oligodendrocyte survival and myelination. Deletion leads to progressive neurological phenotypes and early lethality.
Front. Cell. Neurosci., 2018 • October 16, 2018
The study investigates the effect of inhibiting microglia proliferation via CSF1R blockade (using GW2580) on motor recovery and tissue preservation after spinal cord injury (SCI). GW2580 treatment red...
KEY FINDING: GW2580 treatment inhibits microglia proliferation after SCI.
Stem Cell Reports, 2018 • November 13, 2018
The study focuses on engineering lineage-tracing systems in human embryonic stem cells (hESCs) using genetic recombination techniques. The goal is to specify human developmental principles using an a...
KEY FINDING: The AAVS1 locus in human cells is suitable for integrating conditional reporters for reliable transgene expression during lineage tracing.
Frontiers in Physiology, 2018 • November 16, 2018
This study investigates the effects of Icariin (ICA) on motor recovery in a mouse model of spinal cord injury (SCI). The research hypothesizes that ICA enhances motor recovery by reducing inflammation...
KEY FINDING: ICA enhanced motor recovery at 14, 28, and 42 days after SCI, especially in the high dose group.
Molecular Therapy, 2019 • January 1, 2019
This study demonstrates that increasing LKB1 expression in neurons of adult mice, using viral vectors, promotes significant regeneration of corticospinal tract axons after spinal cord injury. The rese...
KEY FINDING: Overexpression of LKB1, delivered via AAV2 viral vector five days post-spinal cord injury, dramatically enhanced regeneration of corticospinal axons in adult mice.
Frontiers in Neuroscience, 2018 • November 22, 2018
This study demonstrated that systemically injecting miR-133b exosomes preserved neurons, promoted the regeneration of axons, and improved the recovery of hindlimb locomotor function following SCI. The...
KEY FINDING: Systemic injection of miR-133b exosomes improved the recovery of hindlimb locomotor function following SCI.
Neural Regeneration Research, 2019 • February 1, 2019
This study investigates the role of MGMT, a DNA repair enzyme, in all-trans retinoic acid (ATRA)-induced spina bifida aperta (SBA) in rats. The study demonstrates that DNA damage occurs in ATRA-induce...
KEY FINDING: DNA damage, indicated by increased γ-H2A.X levels, occurs in ATRA-induced spina bifida aperta (SBA) embryos.