Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,491-1,500 of 1,773 results
ONCOLOGY LETTERS, 2019 • January 1, 2019
The study characterized the expression profile of ING5 protein in normal mouse and human tissues, and human cancer tissues. ING5 expression was primarily detected in the cytoplasm of normal mouse and ...
KEY FINDING: ING5 expression varies in different tissues, with cytoplasmic localization being more common in normal mouse and human tissues.
Nat Neurosci, 2019 • March 1, 2019
This study elucidates a previously unrecognized function of microvascular endothelial cells in engulfing myelin debris following neural injury, specifically in SCI and EAE models. The process requires...
KEY FINDING: Microvascular endothelial cells act as amateur phagocytes to engulf myelin debris in SCI and EAE, requiring IgG opsonization for effective uptake.
Scientific Reports, 2019 • January 17, 2019
We considered SCI-induced inflammatory mediators as a type of toxin that inhibits the regeneration of injured tissue/cells, and we identified the associated genes and interacting proteins from known b...
KEY FINDING: Tumor necrosis factor (TNF) had the highest scores, and the top 30 were adopted as core data.
International Journal of Molecular Sciences, 2019 • February 2, 2019
This study investigated the use of zonal chondrocyte/mesenchymal progenitor cell constructs in minipigs for the treatment of focal cartilage defects, comparing them to non-zonal grafts and empty contr...
KEY FINDING: Both zonal and non-zonal constructs showed a significantly increased bone loss in the defects when compared to controls, suggesting an osteolytic effect of PCL-enforced implants on the subchondral bone.
Int. J. Biol. Sci., 2019 • January 1, 2019
This study investigates the neuroprotective effects of icariin (ICA) on spinal cord injury (SCI) by attenuating endoplasmic reticulum (ER) stress through the PI3K/AKT signaling pathway. The results de...
KEY FINDING: ICA administration significantly enhanced motor recovery and protected spinal cord tissues against infraction and hemorrhage post injury.
Front. Cell. Neurosci., 2019 • February 4, 2019
This study demonstrates that a conditioning sciatic nerve lesion induces a pro-regenerative state in primary sensory neurons of both lumbar and remote cervical DRG. The pro-regenerative state is chara...
KEY FINDING: A unilateral sciatic nerve injury leads to a bilateral increase in growth-associated protein-43 (GAP-43) and superior cervical ganglion-10 (SCG-10) mRNA and protein levels in both lumbar and cervical DRG neurons.
Curr Top Dev Biol, 2019 • January 1, 2019
The dorsal-ventral axis of the spinal cord is crucial for segregating neurons according to function, with motor neurons in the ventral horn and sensory interneurons in the dorsal horn. Ventral pattern...
KEY FINDING: The ventral spinal cord is patterned by Shh, which acts as a morphogen in a concentration-dependent manner.
Frontiers in Physiology, 2019 • February 8, 2019
This review discusses the biophysical, biochemical, and epigenetic processes involved in regenerative healing in amphibians, particularly tail and limb regeneration in Xenopus. The review highlights t...
KEY FINDING: Reactive oxygen species (ROS) signaling is rapidly activated after injury and is required for tail regeneration. Inhibition of ROS prevents full tail regeneration and affects the activation of Wnt signaling pathways.
Front. Cell. Neurosci., 2019 • February 12, 2019
This study investigates the potential of human iPSC-derived neural progenitor cells (hNPCs) to enhance axon regeneration in the corticospinal tract (CST) by increasing the expression of α9 integrin. T...
KEY FINDING: Increasing α9 integrin expression in human iPSC-derived NPCs enhances neurite outgrowth in vitro, suggesting a functional role for α9 integrin in promoting axon growth.
The Journal of Neuroscience, 2019 • May 1, 2019
This study investigates synaptic plasticity in spinal motor circuits following peripheral nerve injury (PNI), focusing on the role of microglia and CCR2-dependent mechanisms in the removal of Ia affer...
KEY FINDING: Microglia activation around damaged motoneurons starts and peaks within two weeks after nerve damage.