Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 1,391-1,400 of 1,773 results
STEM CELLS AND DEVELOPMENT, 2017 • August 29, 2017
This study investigates the variable neuronal growth support capacities of different mixed astrocyte populations derived from mouse embryonic stem cells (mESCs). Two distinct populations, one primaril...
KEY FINDING: Motoneurons and V2a interneurons extended significantly longer neurites on substrates derived from protoplasmic astrocytes compared to those from fibrous astrocytes.
Scientific Reports, 2017 • August 17, 2017
The study demonstrates that PgP can form polyplexes with pDNA that remain stable in the presence of competing polyanions and provide protection from serum nucleases. PgP/pDNA polyplexes can be stored ...
KEY FINDING: PgP/pDNA polyplexes exhibit increased stability in the presence of a competing anionic macromolecule (heparin) relative to bPEI.
Scientific Reports, 2017 • September 18, 2017
This study demonstrates that α-SNAP is enriched in ovarian granulosa cells and plays a crucial role in folliculogenesis. The hyh mutation of α-SNAP leads to increased granulosa cell apoptosis, prematu...
KEY FINDING: α-SNAP protein is highly expressed in granulosa cells (GCs) of ovarian follicles, and its expression is modulated by gonadotropin stimuli.
Frontiers in Cell and Developmental Biology, 2017 • September 29, 2017
This editorial introduces a research topic on the vascular niche (VN) in tissue repair and regeneration, emphasizing its importance as a therapeutic target. The VN, composed of blood vessels and surro...
KEY FINDING: Organotypic brain slice cultures are a valuable tool to study angiogenesis in the brain.
Molecular Medicine Reports, 2017 • July 5, 2017
This study aimed to investigate the role of miR-99b-5p in SCI and found that its expression is upregulated following SCI in mice. It also identified mTOR as a direct target of miR-99b-5p. The research...
KEY FINDING: miR-99b-5p expression is upregulated in the mouse spinal cord following SCI, suggesting its involvement in the injury response.
Scientific Reports, 2017 • January 1, 2017
This study reports the genome wide transcriptome profile of IL1β induced human spinal cord reactive astrocytes. Comprehensive subnetwork analysis reveals genes, molecular functions, and signaling path...
KEY FINDING: IL1β induction in astrocytes resulted in reactive characteristics within 24 hours.
Frontiers in Pharmacology, 2017 • October 12, 2017
This study presents a novel protocol for obtaining a high yield of oligodendrocyte lineage cells from adult rat meningeal tissue, addressing the need for a readily available source of cells for cell t...
KEY FINDING: A protocol was developed to expand a homogenous culture of 10 millions of meningeal-derived oligodendrocyte lineage cells from 1 cm2 of adult rat spinal cord meninges in approximately 4 weeks.
Comp Biochem Physiol C Toxicol Pharmacol, 2018 • June 1, 2018
This study investigates the molecular basis of positional memory and regeneration timing in axolotl limbs by examining gene expression differences between fore and upper arms during regeneration. The ...
KEY FINDING: Upper arms undergo more robust tissue remodeling and cell proliferation responses after amputation, potentially explaining the similar regeneration times between proximal and distal amputations.
Dev Biol, 2018 • January 15, 2018
This study uncovers a systemic cellular activation response in axolotls following limb amputation, where cells distant from the injury site re-enter the cell cycle. The extent of cellular activation i...
KEY FINDING: Amputation in axolotls induces cell-cycle activation not only in the amputated limb but also in the intact contralateral limb and in other organs like the heart, liver, and spinal cord.
Open Biol., 2017 • October 27, 2017
This study identifies Foxj1a as a general ependymal marker in zebrafish, aiding in tracking ependymal cell responses during spinal cord regeneration. It contrasts with other markers like Sox2, GFAP, a...
KEY FINDING: Foxj1a is expressed in ependymal cells from their genesis in the embryonic neural tube until adulthood in zebrafish.