Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 71-80 of 217 results
Frontiers in Endocrinology, 2022 • June 20, 2022
This study investigates the interaction between melanocortin 1 receptor (Mc1r) and melanocortin receptor-associated proteins (Mraps) in Xenopus tropicalis. The research combines in silico analysis wit...
KEY FINDING: xtMc1r interacts directly with xtMrap1 and xtMrap2 proteins on the plasma membrane, validated through co-immunoprecipitation and fluorescence.
J. Pers. Med., 2022 • June 30, 2022
Cardiometabolic risk and CMS are a significant global public health crisis for the population with SCI. Many people with SCI present with cardiometabolic risk factors, the most serious of which is obe...
KEY FINDING: Obesity after SCI is characterized not just by increased body fat but by the dysregulation of adipose tissue, leading to inflammation, insulin resistance, and other metabolic issues.
Frontiers in Endocrinology, 2022 • July 19, 2022
This cross-sectional study explored the prevalence of indices of sarcopenic obesity in patients with NDS. Our findings revealed statistically significant associations between BMI and SMI in both gende...
KEY FINDING: A statistically significant difference was found in SMI between controls and patients with NDS.
Turk J Phys Med Rehab, 2022 • March 1, 2022
This study investigated the effects of spasticity on glucose metabolism and body composition in patients with spinal cord injury (SCI). The results suggest that spasticity has positive effects on fat-...
KEY FINDING: In patients with motor complete SCI, a positive correlation was found between hip adductor muscle spasticity and trunk, android, and gynoid fat-free mass percentages.
Frontiers in Endocrinology, 2022 • August 5, 2022
This study evaluated the differential expression of miRNAs in subjects with chronic SCI, acute SCI, and no SCI to investigate the association of these miRNAs with SCI mediated osteoporosis and related...
KEY FINDING: MiR-148a-3p was upregulated in subjects with acute SCI vs chronic SCI, as well as in acute SCI vs no SCI.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
This study investigated the relationships between body composition (%FM, %LM, and %FM to %LM ratio), inflammatory markers, and metabolic syndrome in individuals with chronic SCI. The results showed th...
KEY FINDING: Both higher %FM and lower %LM were associated with markers of inflammation (hs-CRP) and metabolic syndrome.
The Journal of Spinal Cord Medicine, 2020 • October 2, 2020
This systematic review aimed to evaluate melatonin levels in individuals with complete cervical SCI compared to healthy controls and those with other types of SCI. The review analyzed 12 studies to as...
KEY FINDING: Adults with complete cervical SCI tend to have absent diurnal melatonin rhythms compared to healthy controls and individuals with thoracolumbar SCI below T3.
JOURNAL OF NEUROTRAUMA, 2019 • December 15, 2019
The study assessed factors associated with circulating BAFF in non-ambulatory males with chronic SCI, finding that active smokers had significantly greater BAFF levels than former/nonsmokers. The rese...
KEY FINDING: Active smokers had significantly greater BAFF levels than former/nonsmokers (871 pg/mL vs. 665 pg/ml, p = 0.002).
Physiological Reports, 2019 • October 1, 2019
This study compared the effects of abaloparatide and teriparatide on bone structure, turnover, and signaling pathways in mice and cells. The results showed that abaloparatide had a greater osteoanabol...
KEY FINDING: Abaloparatide caused a greater dose-dependent increase in cortical thickness than teriparatide.
Spinal Cord Series and Cases, 2019 • October 31, 2019
The article discusses the recently published guidelines for identification and management of cardiometabolic risks after spinal cord injury (SCI). It highlights the inappropriateness of applying gener...
KEY FINDING: Inappropriate application of obesity definitions for the general population to individuals with SCI.