Browse the latest research summaries in the field of dermatology for spinal cord injury patients and caregivers.
Showing 81-90 of 170 results
Cochrane Database of Systematic Reviews, 2020 • January 1, 2020
We identified 20 eligible studies. There is moderate certainty evidence that electrical stimulation (ES) probably increases the proportion of pressure ulcers healed compared with no ES. There is uncer...
KEY FINDING: ES probably increases the proportion of pressure ulcers healed compared with no ES (risk ratio (RR) 1.99, 95% confidence interval (CI) 1.39 to 2.85; I2 = 0%; 11 studies, 501 participants (512 pressure ulcers)).
Med Biol Eng Comput, 2020 • January 1, 2020
This study uses nonnegative matrix factorization (NMF) to predict and visualize pressure ulcer risks in people with spinal cord injury (SCI) based on seating interface pressures. The NMF method identi...
KEY FINDING: NMF basis images encapsulated pressure concentration and pressure dispersion.
Physiological Reports, 2019 • January 1, 2019
This study demonstrates that dendritic spine dysgenesis occurs in ventral horn motor neurons following burn injury, suggesting motor neuron synaptic plasticity. Romidepsin, a Pak1-inhibitor, restored ...
KEY FINDING: Second-degree burn injury significantly affects motor neuron structure within the spinal cord, specifically increasing dendritic spine density.
The Journal of Spinal Cord Medicine, 2021 • January 1, 2021
This retrospective study compared the outcomes of 4-week and 6-week post-flap bedrest protocols for patients with SCI undergoing flap surgery for PIs. The study found that the 4-week protocol resulted...
KEY FINDING: Patients in the 4-week protocol group achieved 2-hour sitting an average of 6 days sooner than those in the 6-week protocol group.
Medicine, 2019 • December 27, 2019
The study evaluated skin atrophy progression in complete Conus-Cauda Syndrome over 8 years and its recovery after 2 years of surface Functional Electrical Stimulation. Quantitative histology showed th...
KEY FINDING: Epidermal atrophy and flattening worsen with increasing years post-spinal cord injury (SCI).
Top Spinal Cord Inj Rehabil, 2020 • July 1, 2020
Skin breakdown, including burns and pressure injuries (PrIs), are devastating complications of spinal cord injury (SCI). Chronic wounds place the person with SCI at high risk of infections, sepsis, an...
KEY FINDING: Skin breakdown is often caused by multiple factors and requires PCPs to familiarize themselves with the individual’s overall health, mobility, and social support.
Frontiers in Medicine, 2021 • March 4, 2021
The study investigates the role of ZBTB20 in itch sensation using PN-ZB20KO mice and gene silencing techniques. It found that ZBTB20 is involved in both histamine- and non-histamine-dependent itch. ZB...
KEY FINDING: Histamine-dependent and non-histamine-dependent itch behaviors were significantly diminished in PN-ZB20KO mice.
Int. J. Mol. Sci., 2022 • December 14, 2022
The study validates that burn injury results in sciatic nerve demyelination and that Schwann cell dedifferentiation increases the expression of the immature marker p75 and reduces that of the maturate...
KEY FINDING: Spinal irisin gene delivery attenuates burn injury-induced sciatic nerve demyelination and reduction of neuromuscular junction innervation.
Spinal Cord Series and Cases, 2020 • May 25, 2020
This retrospective study evaluated the efficacy of coccygectomy for preventing the recurrence of coccygeal pressure ulcers in individuals with paraplegia. The study found that coccygectomy, combined w...
KEY FINDING: Coccygectomy, in addition to rotation flap surgery, is a suitable method for recurrence prevention of pressure ulcer in the coccygeal area.
The Journal of Spinal Cord Medicine, 2015 • January 1, 2015
This retrospective study reviewed the medical records of 1408 patients with SCI, identifying 253 patients who were referred to dermatology for skin lesions. The study aimed to understand dermatologica...
KEY FINDING: The most common dermatological condition was infectious (n = 123, 36.7%) followed by eczematous lesions (n = 109, 32.5%).