Browse the latest research summaries in the field of critical care for spinal cord injury patients and caregivers.
Showing 51-60 of 61 results
Cochrane Database of Systematic Reviews, 2017 • January 3, 2019
We screened 2686 citations and included two trials enrolling 95 participants and one cohort study enrolling 17 participants. One trial reported a statistically significant reduction in mechanical vent...
KEY FINDING: One trial of 75 participants reported that extubation success (defined as no need for reintubation within 48 hours) was higher in the mechanical insufflation-exsufflation (MI-E) group (82.9% versus 52.5%, P < 0.05)
Spinal Cord, 2017 • June 1, 2017
This retrospective study analyzed data from 36 patients with cervical spinal cord injuries (C1-C5) to assess the impact of theophylline treatment on ventilator weaning success, using a non-linear, cat...
KEY FINDING: Ninety-two percent of patients achieved 16 hours ventilator-free breathing (VFB), and 83% achieved 24 hours VFB.
The Journal of Spinal Cord Medicine, 2011 • January 1, 2011
This study assessed the effect of timing and technique of tracheostomy on morbidity, mortality, and resource utilization in patients with acute traumatic spinal cord injuries (SCIs) undergoing mechani...
KEY FINDING: Early tracheostomy (<7 days after intubation) was associated with shorter duration of mechanical ventilation and ICU stay compared to late tracheostomy (≥7 days).
Cureus, 2018 • September 27, 2018
This case report presents the first documented instance of using REBOA in a trauma patient suffering from neurogenic shock. The utilization of REBOA as an adjunct to standard resuscitation methods hel...
KEY FINDING: REBOA was successfully used as an adjunct to manage neurogenic shock in a trauma patient, maintaining cardiac and cerebral perfusion.
Spinal Cord Series and Cases, 2019 • March 11, 2019
This study investigated the clinical care of respiratory dysfunction, oropharyngeal dysphagia and nutrition in CSCI patients within specialized and non-specialized units across the UK. The survey resu...
KEY FINDING: Non-specialized units showed variations in respiratory management, including limited use of vital capacity measures and graduated weaning programs.
J Neuroanaesth Crit Care, 2019 • July 1, 2019
Comprehensive, interdisciplinary care is essential in the ICU to manage the potentially catastrophic multisystem complications of SCI. Early rehabilitation is crucial for patients who survive the init...
KEY FINDING: Maintaining a MAP of 85 to 90 mm Hg for the first 5 to 7 days after injury may improve clinical outcome.
Neurosurgery, 2023 • August 1, 2023
This study investigated the perceived utility of intracranial pressure (ICP) monitoring among experienced neurotraumatologists. The study used a consensus-based approach, polling members of the Seattl...
KEY FINDING: ICP monitor use is wider than predicted by guidelines.
Intensive Care Medicine Experimental, 2024 • January 10, 2024
This review summarizes translational research using zebrafish to study sepsis, organ failure, and trauma, highlighting technologies applicable in this model organism. Zebrafish models allow visualizat...
KEY FINDING: LPS-induced zebrafish endotoxemia results in extravascular migration of neutrophils and macrophages and changes in the expression of tight junction proteins.
Journal of Neuroinflammation, 2016 • September 28, 2016
Post-SCI multiple organ dysfunction is influenced by multifactorial mechanisms, and the extent to which systemic inflammation and immune depression contribute to SCI-associated complications is still ...
KEY FINDING: SCI triggers systemic inflammatory responses, marked by increased immune cells and pro-inflammatory mediators, leading to inflammation in secondary organs.
Intensive Care Med, 2020 • January 21, 2020
This study established three distinct treatment protocols, each with three tiers whereby higher tiers involve therapies with higher risk. One protocol addresses the management of ICP elevation when br...
KEY FINDING: Established three distinct treatment protocols for managing sTBI patients with combined ICP and brain oxygen monitoring: one for ICP elevation with normal brain oxygenation, one for brain hypoxia with normal ICP, and one for both conditions present.