Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 231-240 of 904 results
Signal Transduction and Targeted Therapy, 2022 • April 6, 2022
This study investigates the effectiveness of NT3-chitosan in repairing chronic spinal cord injury (SCI) in rats. The researchers used MR-DTI to monitor lesion area changes and found that NT3-chitosan'...
KEY FINDING: Clearance of the lesion core (via suction of cystic tissues and trimming of solid scar tissues) before introducing NT3-chitosan led to robust neural regeneration and functional recovery.
Adv. Healthcare Mater., 2022 • August 25, 2022
The study addresses the challenge of delivering therapeutic proteins, specifically ChABC, to spinal cord injuries (SCIs) due to their instability. It explores a non-viral mRNA-based method using miner...
KEY FINDING: MCM-mediated mRNA delivery is an efficient non-viral gene delivery method in primary neural cells in vitro and enabled localized transgene expression in the glial scar in vivo.
Frontiers in Robotics and AI, 2022 • July 22, 2022
This study aimed to develop a multimodal control system to assist individuals with restricted mobility in performing ADL while having control over their mobility and environment. The proposed control ...
KEY FINDING: The absolute position accuracy of the robotic system was experimentally found to be approximately 5 mm.
Frontiers in Neuroscience, 2022 • August 24, 2022
This study introduces an adaptive reflexive control strategy for a multiple-channel FES walking assistance system. It aims to improve gait rehabilitation by adjusting electrical stimulation parameters ...
KEY FINDING: The adaptive FES controller effectively adjusts stimulation sequences for individual participants at various treadmill walking speeds.
Assist Technol., 2020 • September 2, 2020
This study investigated the effects of wheelchair tilt and recline combinations on seating pressure gradients (PPGs) in individuals with spinal cord injury (SCI). The research focused on both the magn...
KEY FINDING: Wheelchair recline is more effective at reducing the magnitude of peak pressure gradients (PPGs) under the ischial tuberosity.
Scientific Reports, 2019 • September 1, 2019
This paper describes a novel FES standing exercise system for SCI users which was validated as a platform for investigation of bone health. The standing frame improved work from previous systems, allo...
KEY FINDING: We observed ground reaction forces over 70% of the full body-weight distributed to the supporting leg at each exercising cycle.
Journal of NeuroEngineering and Rehabilitation, 2019 • December 12, 2019
This study presents a novel 3D-printed myoelectric hand orthosis designed to improve hand function in patients with cervical SCI. The orthosis utilizes EMG signals to control a tenodesis grip, offerin...
KEY FINDING: The 3D-printed myoelectric orthosis improved hand function in subjects, as determined using the TRI-HFT (p < 0.05).
Theranostics, 2019 • September 21, 2019
This study introduces a novel injectable hydrogel (Lap/Hep@FGF4) designed for sustained release of FGF4 at the site of spinal cord injury (SCI). The hydrogel is composed of heparin and Laponite, which...
KEY FINDING: The Lap/Hep@FGF4 group showed remarkable motor functional recovery and axonal regrowth after SCI through suppressing inflammatory reaction, increasing remyelination and reducing glial/fibrotic scars.
Neurology, 2023 • March 14, 2023
This study presents the interim safety profile of the BrainGate Neural Interface System, a brain-computer interface (BCI) designed to restore mobility and communication in individuals with paralysis. ...
KEY FINDING: The BrainGate trial, involving 14 adults, showed an average device implantation duration of 872 days, totaling 12,203 days of safety experience. The most common device-related adverse event was skin irritation around the percutaneous pedestal.
Med Biol Eng Comput, 2020 • January 1, 2020
This study uses nonnegative matrix factorization (NMF) to predict and visualize pressure ulcer risks in people with spinal cord injury (SCI) based on seating interface pressures. The NMF method identi...
KEY FINDING: NMF basis images encapsulated pressure concentration and pressure dispersion.