Biomedical Research

KEY FINDING: The imaging and planning procedures successfully enabled ICMS-evoked sensations localized to at least the first four digits of the hand in all five participants.

KEY FINDING: The generated pulsed electrical signals promote the differentiation of NSCs into functional mature neurons and increase the proportion of neurons from 12.5% to 33.7%.

KEY FINDING: IMUs, motion sensors, 3D motion capture systems, and observational gait analysis can effectively assess changes in step velocity and step length in elderly individuals.

KEY FINDING: Single-cathode extraneural electrical stimulation of the sciatic nerve can activate combined movements to promote lower limb movements in rats.

KEY FINDING: SPIO persisted in GRNs for a minimum of 24 weeks without inducing apoptosis of GRN cells, and degraded slowly over time.

KEY FINDING: BCI-FES systems promote nerve function reconstruction by connecting motor intention and muscle contraction.

KEY FINDING: A biohybrid nerve with a 1:1 ratio of FeCl3 to EDOT, cycled twice (DNP1:1C2), exhibited superior conductivity, mechanical alignment, and biocompatibility.

KEY FINDING: A modular NP system was developed, characterized by its flexibility, scalability, and personalization capabilities, with excellent connection characteristics for integration with robotic devices.

KEY FINDING: NeuroStep partially restored lost sensations in all 14 PN participants through targeted neurostimulation at the ankle level.

KEY FINDING: LNT M2/PTX-NPs@Gel treatment significantly improved motor function recovery in SCI rats, as evidenced by increased BBB scores and MEP amplitudes.