Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 21-30 of 334 results
Int. J. Mol. Sci., 2025 • March 13, 2025
This study aimed to elucidate the molecular mechanisms underlying the combined use of LGZ and SIN in treating NP using network pharmacology and metabolomics. The combination of LGZ and SIN demonstrate...
KEY FINDING: The combination of LGZ and SIN significantly alleviated pain-like behaviors in CCI rats in a time- and dose-dependent manner, demonstrating superior therapeutic effects compared to LGZ or SIN alone.
Global Spine Journal, 2023 • January 1, 2023
This study evaluated the use of synthetic data derivatives for spine surgery research by comparing real and synthetic data from anterior cervical and posterior lumbar fusion patients. The results show...
KEY FINDING: Descriptive characteristics were nearly identical between the real and synthetic cervical fusion datasets, with only small but statistically significant differences in race and recent hospital/ED visits.
J Neurosurg Spine, 2022 • October 1, 2022
This study investigates the use of Diffusion Basis Spectrum Imaging (DBSI) in combination with clinical metrics to predict outcomes of cervical decompression surgery for Cervical Spondylotic Myelopath...
KEY FINDING: The SVM trained with clinical and DBSI metrics achieved an accuracy of 88.1% and an area under the curve of 0.95 in predicting patient outcomes.
Materials Today Bio, 2024 • June 8, 2024
This study addresses the challenge of accurately measuring microglial activation in preclinical SCI models by proposing a deep learning-based technique. The developed application simplifies and ensure...
KEY FINDING: A deep learning-based technique can quantify microglial activation following drug-loaded nanovector treatment in a preclinical SCI model.
European Journal of Medical Research, 2022 • August 4, 2022
This study analyzes gene expression changes in two different rat models of spinal cord injury (SCI) using RNA sequencing. The researchers found distinct gene expression patterns in the two SCI models,...
KEY FINDING: The study identified significant differences in gene expression between the two SCI models, particularly within the first two weeks after injury.
BMC Neuroscience, 2022 • August 1, 2022
This study aimed to identify hub genes and signaling pathways involved in subacute SCI in rats using bioinformatics methods to provide a molecular basis for future SCI treatments. The researchers anal...
KEY FINDING: A total of 206 candidate genes were identified as differentially expressed in subacute SCI, including 164 up-regulated and 42 down-regulated genes.
Diagnostics, 2022 • August 31, 2022
The study developed a diagnostic support tool for DCM using grip strength and GRT measurements from DCM surgery patients and healthy controls. GRT and grip strength showed good diagnostic accuracy ind...
KEY FINDING: The diagnostic support tool, combining GRT and grip strength, showed an overall sensitivity of 88.2% and a specificity of 78.1% in diagnosing DCM.
Frontiers in Immunology, 2022 • October 5, 2022
This study identifies and characterizes aging/senescence-induced genes (ASIGs) in osteosarcoma to predict clinical prognosis. The researchers used data from public databases to identify three molecula...
KEY FINDING: The study identified three distinct molecular subgroups of osteosarcoma based on the expression of aging/senescence-induced genes (ASIGs), each exhibiting varying levels of immune infiltration.
Ann Transl Med, 2022 • September 1, 2022
This study used iTRAQ proteomics to analyze the proteome profiles of BMSCs cocultured with SCs, identifying 243 differentially expressed proteins (DEPs). Bioinformatics analyses (GO and KEGG) indicate...
KEY FINDING: A total of 6,760 types of proteins were detected, with 5,181 having quantitative information. Among these, 243 DEPs were identified.
Cells, 2022 • December 19, 2022
The study investigated the expression and distribution of 2-AG in the brain and spinal cord of a spare nerve injury (SNI) mice model of neuropathic pain using DESI-MSI. The results showed that 2-AG ex...
KEY FINDING: On days 3 and 7 after SNI treatment, 2-AG expression decreased in the hypothalamus, midbrain, and especially in the periaqueductal gray (PAG) region.